Medicine Information

Cilmedip

Name: Cilmedip
Brand: Cilmedip
Rating: 4.5 (117 reviews)

Tablet10 mgAntihypertensive, Calcium Channel BlockerATC: C08CA14

Generic Name

Cilnidipine 10 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cilmedip 10 mg tablet	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Cilnidipine 10 mg Tablet is an antihypertensive medication used to treat high blood pressure (hypertension). It belongs to a class of drugs called calcium channel blockers.

Uses & Indications

Essential Hypertension

Dosage

Adults

Usually 5-10 mg orally once daily. May be increased to a maximum of 20 mg once daily if necessary.

Elderly

Initiate with a lower dose (e.g., 5 mg once daily) and adjust according to response and tolerability.

Renal_impairment

No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe impairment; consider lower starting dose.

How to Take

Take orally, preferably in the morning, with or without food. Swallow the tablet whole with water.

Mechanism of Action

Cilnidipine selectively blocks L-type and N-type voltage-dependent calcium channels present in vascular smooth muscle cells and nerve endings. This leads to peripheral vasodilation, reduced sympathetic nerve activity, and ultimately a decrease in blood pressure.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted as metabolites in urine (approx. 60%) and feces (approx. 40%).

Half life

Approximately 6-8 hours (terminal half-life)

Absorption

Rapidly absorbed after oral administration. Peak plasma concentration reached within 1.5-3 hours.

Metabolism

Extensively metabolized in the liver, primarily by CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to Cilnidipine or other dihydropyridine derivatives.
Cardiogenic shock.
Severe aortic stenosis.
Unstable angina.
Severe hepatic impairment.

Drug Interactions

Digoxin

No significant interaction reported, but monitor digoxin levels.

Other Antihypertensives

Concomitant use may lead to additive hypotensive effects.

CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)

May decrease Cilnidipine plasma concentrations, potentially reducing its efficacy.

CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)

May increase Cilnidipine plasma concentrations, leading to enhanced hypotensive effect. Dose adjustment may be necessary.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include excessive vasodilation with marked hypotension and possibly reflex tachycardia. Management is supportive, including gastric lavage, activated charcoal, and intravenous fluids for hypotension. Close monitoring of vital signs.

Pregnancy & Lactation

Pregnancy Category C. Not recommended during pregnancy or lactation unless the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip3 strips (30 tablets) per box

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Generic available

Clinical Trials

Cilnidipine has undergone various clinical trials demonstrating its efficacy and safety in managing essential hypertension. Ongoing research may explore its additional benefits.

Lab Monitoring

Blood pressure monitoring
Renal function (BUN, creatinine)
Liver function tests (ALT, AST)

Doctor Notes

Advise patients on lifestyle modifications (diet, exercise, smoking cessation).
Monitor blood pressure and signs of peripheral edema regularly.
Caution in patients with severe hepatic or renal impairment.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor.
Monitor your blood pressure regularly as advised by your healthcare provider.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness or drowsiness, especially at the start of treatment or when changing doses. Avoid driving or operating machinery if you experience these symptoms.

Lifestyle Advice

Adopt a healthy lifestyle including a balanced diet low in sodium, regular exercise, and stress management.
Avoid excessive alcohol consumption.
Quit smoking.