Cinagen XG
Generic Name
Cinnarizine + Dimenhydrinate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinagen xg 05 04 eye drop | ৳ 150.00 | N/A |
Description
Overview of the medicine
Cinagen XG is a combination medicine containing Cinnarizine and Dimenhydrinate, primarily used for the symptomatic treatment of vertigo, dizziness, tinnitus, and nausea and vomiting associated with Meniere's disease or motion sickness.
Uses & Indications
Dosage
Adults
One tablet (Cinnarizine 20 mg + Dimenhydrinate 40 mg) 2-3 times daily, preferably after meals. Do not exceed 3 tablets per day.
Elderly
Same as adults, with caution. Close monitoring for adverse effects is recommended.
Renal_impairment
Use with caution. Dose adjustment may be necessary in severe renal impairment. Consult a doctor.
Hepatic_impairment
Use with caution. Dose adjustment may be necessary in severe hepatic impairment. Consult a doctor.
How to Take
Take orally with water, preferably after meals to minimize gastrointestinal discomfort. Do not chew or crush the tablet.
Mechanism of Action
Cinnarizine is a calcium channel blocker and antihistamine that inhibits vestibular stimulation. Dimenhydrinate is an H1-receptor antagonist with antiemetic and anticholinergic properties. The combination works synergistically to suppress vestibular function and reduce nausea and vomiting.
Pharmacokinetics
Onset
Onset of action typically occurs within 30 minutes to 2 hours.
Excretion
Primarily excreted in the urine, with some fecal excretion.
Half life
Cinnarizine has a plasma half-life of approximately 4 hours. Dimenhydrinate's half-life is around 4-6 hours.
Absorption
Both cinnarizine and dimenhydrinate are well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Both drugs are extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cinnarizine, dimenhydrinate, or other antihistamines.
- Patients with narrow-angle glaucoma.
- Patients with prostatic hypertrophy.
- Acute porphyria.
- Children under 12 years of age.
Drug Interactions
0
CNS depressants (alcohol, sedatives, hypnotics): May potentiate sedative effects.
1
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine): Increased anticholinergic effects.
2
Monoamine Oxidase Inhibitors (MAOIs): May prolong and intensify the anticholinergic effects of dimenhydrinate.
3
Antihypertensives: May enhance the hypotensive effect.
4
Aminoglycoside antibiotics: May mask ototoxicity symptoms.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, CNS depression, dry mouth, blurred vision, tachycardia, and in severe cases, seizures or coma. Management involves supportive care, gastric lavage, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B/C. Not recommended during pregnancy unless clearly necessary. Small amounts may pass into breast milk; caution is advised during lactation. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cinnarizine, dimenhydrinate, or other antihistamines.
- Patients with narrow-angle glaucoma.
- Patients with prostatic hypertrophy.
- Acute porphyria.
- Children under 12 years of age.
Drug Interactions
0
CNS depressants (alcohol, sedatives, hypnotics): May potentiate sedative effects.
1
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine): Increased anticholinergic effects.
2
Monoamine Oxidase Inhibitors (MAOIs): May prolong and intensify the anticholinergic effects of dimenhydrinate.
3
Antihypertensives: May enhance the hypotensive effect.
4
Aminoglycoside antibiotics: May mask ototoxicity symptoms.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, CNS depression, dry mouth, blurred vision, tachycardia, and in severe cases, seizures or coma. Management involves supportive care, gastric lavage, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B/C. Not recommended during pregnancy unless clearly necessary. Small amounts may pass into breast milk; caution is advised during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies across Bangladesh
Approval Status
Approved (Bangladesh DGDA)
Patent Status
Generic available
Clinical Trials
Clinical trials have shown the efficacy of cinnarizine-dimenhydrinate combination in treating vertigo and motion sickness symptoms, demonstrating superior efficacy compared to monotherapy with either agent.
Lab Monitoring
- Routine lab monitoring is generally not required. Liver and kidney function tests may be considered in patients with pre-existing impairment during long-term use.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring alertness.
- Consider dose adjustment in elderly and patients with hepatic/renal impairment.
- Educate patients on drug interactions, especially with CNS depressants.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol and other CNS depressants while taking this medicine.
- Be cautious when driving or operating machinery due to potential drowsiness.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine can cause drowsiness and dizziness. Patients should be warned about driving or operating dangerous machinery until they know how this medicine affects them.
Lifestyle Advice
- Avoid activities requiring mental alertness immediately after taking the medicine if you experience drowsiness. Stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.