Cinalid
Generic Name
Cinalid Hydrochloride
Manufacturer
Pharmatech Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinalid 200 mg suspension | ৳ 75.50 | N/A |
Description
Overview of the medicine
Cinalid 200 mg Suspension is a macrolide antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Adults: 200-400 mg once daily for 5-10 days, depending on infection severity.
Elderly
No specific dose adjustment required based on age alone; monitor renal/hepatic function.
Renal_impairment
Mild to moderate impairment: No dose adjustment. Severe impairment: Use with caution, dose reduction may be necessary.
How to Take
Shake the bottle well before each use. Administer orally, preferably with or without food. Complete the full course of medication even if symptoms improve.
Mechanism of Action
Cinalid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms. This prevents the translocation of peptidyl-tRNA, thus stopping peptide chain elongation.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly through bile and feces, a small portion via urine
Half life
Approximately 8-12 hours
Absorption
Well absorbed from the gastrointestinal tract, bioavailability is approximately 40-60%. Food can affect absorption.
Metabolism
Primarily hepatic, via CYP3A4
Side Effects
Contraindications
- Known hypersensitivity to Cinalid or any other macrolide antibiotics
- Severe hepatic dysfunction
- Concomitant use with drugs that prolong QT interval (e.g., cisapride, terfenadine)
Drug Interactions
Digoxin
May increase digoxin levels, monitor for toxicity.
Warfarin
May increase anticoagulant effect, requiring INR monitoring.
Statins (e.g., simvastatin)
Increased risk of myopathy/rhabdomyolysis due to CYP3A4 inhibition.
Antacids (containing aluminum or magnesium)
May reduce Cinalid absorption, administer at least 2 hours apart.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include severe gastrointestinal upset, hearing loss, and abnormal liver function. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; consider risks/benefits before use during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Cinalid or any other macrolide antibiotics
- Severe hepatic dysfunction
- Concomitant use with drugs that prolong QT interval (e.g., cisapride, terfenadine)
Drug Interactions
Digoxin
May increase digoxin levels, monitor for toxicity.
Warfarin
May increase anticoagulant effect, requiring INR monitoring.
Statins (e.g., simvastatin)
Increased risk of myopathy/rhabdomyolysis due to CYP3A4 inhibition.
Antacids (containing aluminum or magnesium)
May reduce Cinalid absorption, administer at least 2 hours apart.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include severe gastrointestinal upset, hearing loss, and abnormal liver function. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; consider risks/benefits before use during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture. Once reconstituted, use within 7-10 days.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Cinalid has undergone various clinical trials demonstrating its efficacy and safety in treating bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Liver function tests (LFTs) if prolonged treatment or hepatic impairment
- Renal function tests if renal impairment
- Complete Blood Count (CBC) in long-term therapy
Doctor Notes
- Emphasize the importance of completing the full course to patients.
- Counsel on potential GI side effects and management strategies.
- Be aware of potential drug interactions, especially with warfarin and statins.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Complete the entire course of medication, even if you feel better, to prevent recurrence and resistance.
- Do not share your medication with others.
- Report any severe side effects immediately to your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Generally, Cinalid does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate side effects.
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