Cinaron Plus
Generic Name
Cinnarizine + Dimenhydrinate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cinaron plus 20 mg tablet | ৳ 2.00 | ৳ 28.00 |
Description
Overview of the medicine
Cinaron Plus is a combination medicine containing Cinnarizine and Dimenhydrinate, used to treat symptoms of vertigo, dizziness, tinnitus, nausea, and vomiting associated with Meniere's disease and other vestibular disorders.
Uses & Indications
Dosage
Adults
One tablet two to three times daily. Maximum daily dose should not exceed 5 tablets.
Elderly
Same as adult dose, but caution is advised due to increased risk of side effects.
Renal_impairment
Use with caution. Dose adjustment might be necessary in severe renal impairment.
How to Take
To be taken orally, preferably after meals with some liquid, to reduce gastric irritation.
Mechanism of Action
Cinnarizine acts as a calcium channel blocker, inhibiting calcium influx into vestibular sensory cells, thereby reducing vestibular stimulation. It also has antihistaminic properties. Dimenhydrinate is an antihistamine (H1 receptor antagonist) with anticholinergic and antiemetic effects, primarily acting on the chemoreceptor trigger zone and vestibular nuclei.
Pharmacokinetics
Onset
Effects typically begin within 30-60 minutes after oral administration.
Excretion
Both drugs and their metabolites are primarily excreted in the urine.
Half life
Cinnarizine: 4-24 hours. Dimenhydrinate: 1-4 hours.
Absorption
Cinnarizine is slowly absorbed from the gastrointestinal tract, reaching peak plasma levels in 1-3 hours. Dimenhydrinate is well absorbed after oral administration, with effects usually noted within 30 minutes.
Metabolism
Both Cinnarizine and Dimenhydrinate are extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cinnarizine, Dimenhydrinate, or other antihistamines
- Acute angle-closure glaucoma
- Urinary retention due to prostatic disorders
- Pyloroduodenal obstruction
- Epilepsy
- Children under 5 years of age
- Pregnancy and lactation (unless specifically advised by a physician)
Drug Interactions
Alcohol
Increased sedative effects.
Ototoxic drugs (e.g., aminoglycoside antibiotics)
May mask the warning signs of ototoxicity (e.g., tinnitus, dizziness).
CNS depressants (e.g., barbiturates, benzodiazepines, opioids)
Potentiated sedation and drowsiness.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
Increased anticholinergic effects (dry mouth, blurred vision, urinary retention).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, atropine-like effects (e.g., dry mouth, blurred vision, urinary retention), and in children, CNS excitation (e.g., convulsions, hallucinations). Management involves supportive care, gastric lavage, activated charcoal, and symptomatic treatment.
Pregnancy & Lactation
Use with caution. This medicine should not be used during pregnancy or lactation unless the potential benefits outweigh the risks and is advised by a healthcare professional.
Side Effects
Contraindications
- Hypersensitivity to Cinnarizine, Dimenhydrinate, or other antihistamines
- Acute angle-closure glaucoma
- Urinary retention due to prostatic disorders
- Pyloroduodenal obstruction
- Epilepsy
- Children under 5 years of age
- Pregnancy and lactation (unless specifically advised by a physician)
Drug Interactions
Alcohol
Increased sedative effects.
Ototoxic drugs (e.g., aminoglycoside antibiotics)
May mask the warning signs of ototoxicity (e.g., tinnitus, dizziness).
CNS depressants (e.g., barbiturates, benzodiazepines, opioids)
Potentiated sedation and drowsiness.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
Increased anticholinergic effects (dry mouth, blurred vision, urinary retention).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, atropine-like effects (e.g., dry mouth, blurred vision, urinary retention), and in children, CNS excitation (e.g., convulsions, hallucinations). Management involves supportive care, gastric lavage, activated charcoal, and symptomatic treatment.
Pregnancy & Lactation
Use with caution. This medicine should not be used during pregnancy or lactation unless the potential benefits outweigh the risks and is advised by a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic available
Clinical Trials
The combination of cinnarizine and dimenhydrinate has been clinically tested and shown to be effective in treating vertigo and related symptoms. Several studies support its efficacy and safety profile in adult patients.
Lab Monitoring
- No specific routine laboratory monitoring is usually required.
- Monitor liver function in patients with pre-existing liver impairment or during prolonged high-dose therapy.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness like driving or operating machinery.
- Caution in patients with liver or renal impairment; dosage adjustment may be needed.
- Monitor for anticholinergic side effects, especially in elderly patients.
- Not recommended for children under 5 years.
- Advise patients not to abruptly stop medication if using for Meniere's disease without consulting a doctor.
Patient Guidelines
- Do not drive or operate heavy machinery if you experience drowsiness or dizziness.
- Avoid alcohol consumption while taking this medicine.
- Inform your doctor about all other medications, including herbal supplements, you are taking.
- Take the medicine as prescribed and do not exceed the recommended dose.
- If symptoms do not improve after a few days, consult your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness and dizziness. Patients should be warned not to drive or operate heavy machinery if affected.
Lifestyle Advice
- Avoid sudden head movements that may trigger or worsen vertigo.
- Ensure adequate hydration.
- Manage stress levels and get sufficient rest.
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Global Brand Names
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