Cipro
Generic Name
Ciprofloxacin 500 mg Tablet
Manufacturer
Various (e.g., Bayer, Square, Incepta)
Country
Global (including Bangladesh)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cipro 500 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Ciprofloxacin 500 mg tablet is an antibiotic used to treat various bacterial infections, including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and gastrointestinal infections. It belongs to the fluoroquinolone class of antibiotics.
Uses & Indications
Dosage
Adults
Typical dosage is 500 mg twice daily, depending on the severity and type of infection. Treatment duration varies.
Elderly
No specific dose adjustment for elderly patients based on age alone, but renal function should be assessed.
Renal_impairment
Dose adjustment necessary for patients with severe renal impairment (Creatinine Clearance < 30 mL/min).
How to Take
Take orally with a glass of water, with or without food. Avoid taking with dairy products or calcium-fortified juices. Do not crush or chew the tablet.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Clinical effects usually within 1-2 hours, full therapeutic effect within days depending on infection.
Excretion
Primarily excreted unchanged by the kidneys (50-70%) and to a lesser extent via the feces (15-20%).
Half life
Approximately 3-5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Undergoes limited hepatic metabolism (15-30%) to four active metabolites.
Side Effects
Contraindications
- •Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- •Concomitant administration with tizanidine.
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
Increased anticoagulant effect, leading to bleeding.
Tizanidine
Increased risk of hypotension and somnolence.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids/Mineral supplements (containing aluminum, magnesium, calcium, iron, zinc)
Reduced absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric emptying (e.g., induced vomiting or gastric lavage) may be considered. Symptomatic treatment and supportive care should be provided. Adequate hydration should be maintained.
Pregnancy & Lactation
Not recommended during pregnancy due to potential risks to fetal cartilage development, unless the benefits outweigh the risks. Ciprofloxacin is excreted into breast milk and is generally not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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