Cipron
Generic Name
Ciprofloxacin 250 mg Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cipron 250 mg suspension | ৳ 90.01 | N/A |
Description
Overview of the medicine
Cipron 250 mg Suspension contains Ciprofloxacin, a fluoroquinolone antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typical adult oral dosage ranges from 250 mg to 750 mg twice daily, depending on the infection severity and site.
Elderly
Similar to adult dosage, but dose adjustment may be necessary in case of renal impairment.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl < 30 mL/min, administer half the usual dose.
How to Take
Shake the suspension well before each use. Administer orally, usually with or without food. Avoid taking with dairy products or calcium-fortified juices alone.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily excreted renally (approximately 50-70% as unchanged drug) and to a lesser extent via the feces (15%).
Half life
Approximately 3-5 hours
Absorption
Rapidly and well absorbed after oral administration. Bioavailability is approximately 70-80%.
Metabolism
Partially metabolized in the liver to four active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin, and formylciprofloxacin).
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with Tizanidine
- Children and adolescents (due to risk of arthropathy, unless benefits outweigh risks)
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, increased risk of bleeding.
Tizanidine
Increased plasma concentrations of Tizanidine, leading to hypotension and somnolence.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids/Mineral supplements (containing Mg, Al, Ca, Fe, Zn)
Decreased absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of acute oral overdose, gastric emptying by induced emesis or gastric lavage may be considered. Support measures such as ensuring adequate hydration and maintaining renal function should be instituted. Hemodialysis or peritoneal dialysis remove only small amounts of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. Nursing mothers should discontinue nursing or the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with Tizanidine
- Children and adolescents (due to risk of arthropathy, unless benefits outweigh risks)
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, increased risk of bleeding.
Tizanidine
Increased plasma concentrations of Tizanidine, leading to hypotension and somnolence.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids/Mineral supplements (containing Mg, Al, Ca, Fe, Zn)
Decreased absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of acute oral overdose, gastric emptying by induced emesis or gastric lavage may be considered. Support measures such as ensuring adequate hydration and maintaining renal function should be instituted. Hemodialysis or peritoneal dialysis remove only small amounts of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. Nursing mothers should discontinue nursing or the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for unopened product, check package for specific expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for its efficacy and safety across various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with renal impairment
- Liver function tests (LFTs) if liver dysfunction is suspected
- CBC and coagulation parameters if used with anticoagulants
Doctor Notes
- Educate patients about the risk of tendinopathy and peripheral neuropathy.
- Consider drug interactions, especially with Tizanidine, Warfarin, and antacids.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Drink plenty of fluids to prevent crystalluria.
- Avoid excessive exposure to sunlight or artificial UV light during treatment.
- Report any tendon pain, swelling, or inflammation immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, which could impair the ability to drive or operate machinery. Patients should be advised to know how they react to ciprofloxacin before driving or engaging in hazardous activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid strenuous physical activity if you experience joint or tendon pain.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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