Ciprosic
Generic Name
Ciprofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ciprosic 750 mg tablet | ৳ 17.50 | ৳ 175.00 |
Description
Overview of the medicine
Ciprosic 750 mg tablet is an antibiotic belonging to the fluoroquinolone class. It is used to treat a wide range of bacterial infections including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and gastrointestinal infections. It works by killing the bacteria that cause these infections.
Uses & Indications
Dosage
Adults
The dosage of Ciprosic 750 mg varies based on the type and severity of infection. For severe or complicated infections (e.g., complicated UTIs, bone/joint infections), the typical adult oral dosage is 750 mg twice daily for 7 to 14 days or longer depending on the infection. Always follow doctor's instructions.
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function. However, dosage should be adjusted based on renal function if impaired.
Renal_impairment
For patients with creatinine clearance less than 30 mL/min, the dosage should be reduced to 750 mg once daily or adjusted according to the prescribing information, to prevent accumulation.
How to Take
Take Ciprosic 750 mg tablet orally with a glass of water, whole, and do not crush, split, or chew. It can be taken with or without food. Avoid taking it with dairy products or calcium-fortified juices as these can reduce absorption. Take it at least 2 hours before or 6 hours after taking antacids or other products containing magnesium, aluminum, calcium, iron, or zinc.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA processes and ultimately bacterial cell death, making it a bactericidal agent.
Pharmacokinetics
Onset
Antibacterial effect typically observed within 1-2 hours of administration.
Excretion
Primarily excreted renally (50-70% as unchanged drug) and to a lesser extent via the feces (15-30%).
Half life
Approximately 3-5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract (bioavailability 70-80%). Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Approximately 15-30% metabolized in the liver to four active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin, and formylciprofloxacin) which have less antimicrobial activity than the parent drug.
Side Effects
Contraindications
- •Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- •Concomitant administration of tizanidine (due to risk of severe hypotension and somnolence).
- •History of tendinitis or tendon rupture associated with fluoroquinolone use.
Drug Interactions
Caffeine
Decreased clearance of caffeine, leading to increased caffeine effects.
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk. Monitor INR.
Tizanidine
Increased risk of hypotension and somnolence. Concomitant use is contraindicated.
Theophylline
Increased plasma concentrations of theophylline, leading to increased risk of toxicity. Monitor theophylline levels.
Antacids, iron, zinc supplements
Reduced absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsive seizures.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an acute overdose, symptoms may include kidney damage. Gastric lavage and supportive treatment are recommended. Adequate hydration should be maintained. Hemodialysis or peritoneal dialysis remove only small amounts of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into human breast milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the specific manufacturer's guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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