Ciprozid-DS
Generic Name
Ciprofloxacin
Manufacturer
The Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ciprozid ds 500 mg tablet | ৳ 15.05 | ৳ 150.50 |
Description
Overview of the medicine
Ciprozid-DS is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections, including urinary tract, respiratory, skin, bone and joint, and gastrointestinal infections.
Uses & Indications
Dosage
Adults
For Ciprozid-DS (750 mg), typical adult dosage is 750 mg orally once or twice daily depending on the type and severity of infection, for a duration of 7-14 days. For complicated UTIs, 750 mg once daily for 5-10 days.
Elderly
Dose adjustment may be necessary based on renal function. Elderly patients may be at increased risk of adverse effects.
Renal_impairment
Dose reduction is required for patients with creatinine clearance < 30 mL/min. For example, 750 mg every 24-48 hours depending on the indication.
How to Take
Administer orally with or without food. To minimize stomach upset, it may be taken with food. Do not take with dairy products (milk, yogurt) or calcium-fortified juices alone. Take at least 2 hours before or 6 hours after antacids or supplements containing magnesium, aluminum, calcium, iron, or zinc.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Antibacterial effects typically begin within 1-2 hours.
Excretion
Primarily renal excretion (50-70% unchanged drug in urine); some fecal excretion (15-30%) for unabsorbed drug and metabolites.
Half life
Approximately 3-5 hours.
Absorption
Well absorbed orally, with approximately 70-80% bioavailability. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Limited hepatic metabolism; primarily forms less active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin).
Side Effects
Contraindications
- •Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- •Co-administration with tizanidine due to increased risk of hypotension and somnolence.
- •History of tendinitis or tendon rupture associated with fluoroquinolone use.
- •Myasthenia gravis, as it may exacerbate muscle weakness.
Drug Interactions
0
Antacids, sucralfate, didanosine (chewable/buffered tablets), metal cations (iron, zinc, calcium): Significantly reduce ciprofloxacin absorption. Take ciprofloxacin at least 2 hours before or 6 hours after these agents.
1
Theophylline: Ciprofloxacin can increase plasma concentrations of theophylline, leading to toxicity. Monitor theophylline levels.
2
Warfarin: May enhance the anticoagulant effect of warfarin. Monitor INR regularly.
3
NSAIDs (non-steroidal anti-inflammatory drugs): Concomitant use may increase the risk of CNS stimulation and convulsive seizures.
4
Corticosteroids: Increased risk of tendinitis and tendon rupture when used concurrently.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
In case of acute oral overdose, gastric lavage may be considered to remove unabsorbed drug. Provide supportive care and maintain adequate hydration. Hemodialysis or peritoneal dialysis is not effective in removing ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C: Use only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk and may harm a nursing infant (e.g., joint damage). A decision should be made whether to discontinue nursing or to discontinue the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the manufacturing date, when stored properly.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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