Cispenam
Generic Name
cispenam-250-mg-injection
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cispenam 250 mg injection | ৳ 650.00 | N/A |
Description
Overview of the medicine
Cispenam 250 mg Injection is a broad-spectrum carbapenem antibiotic used to treat a wide range of severe bacterial infections, including those resistant to other antibiotics. It is administered intravenously.
Uses & Indications
Dosage
Adults
The usual intravenous dose for adults is 500 mg to 1 g every 8 hours, depending on the type and severity of infection. For certain mild to moderate infections or in specific cases, 250 mg may be considered, often in pediatric patients or those with renal impairment requiring dose adjustment.
Elderly
Dose adjustment based on renal function is generally recommended for elderly patients.
Renal_impairment
Significant dose reduction is required for patients with creatinine clearance less than 50 mL/min. Specific dosing guidelines should be followed based on the degree of impairment.
How to Take
Cispenam 250 mg Injection is for intravenous use only. It can be administered as an intravenous bolus over 3-5 minutes or as an intravenous infusion over 15-30 minutes. The specific route and duration depend on the dose and patient's condition.
Mechanism of Action
Meropenem (the active ingredient) is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to the disruption of the cell wall and subsequent bacterial cell death.
Pharmacokinetics
Onset
Rapid.
Excretion
Approximately 70% of the administered dose is excreted unchanged in the urine within 12 hours.
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Minimally metabolized; primarily hydrolyzed to an inactive open-ring metabolite.
Side Effects
Contraindications
- Hypersensitivity to meropenem or any other carbapenem antibiotics.
- Patients with a history of severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibiotic (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem. Co-administration is not recommended.
Valproic acid
Concomitant administration with meropenem may decrease valproic acid levels below the therapeutic range, increasing the risk of seizures. Co-administration is generally not recommended.
Oral anticoagulants
Concurrent use with meropenem may enhance the anticoagulant effect of warfarin and other oral anticoagulants.
Storage
Store below 25°C. Protect from light and moisture. Reconstituted solutions should be used immediately or stored as per manufacturer's instructions, usually for a limited period under refrigeration.
Overdose
Limited experience with meropenem overdose. In the event of an overdose, discontinue meropenem and initiate general supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Meropenem should be used during pregnancy only if clearly needed and after careful risk-benefit assessment by a physician. It is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to meropenem or any other carbapenem antibiotics.
- Patients with a history of severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibiotic (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem. Co-administration is not recommended.
Valproic acid
Concomitant administration with meropenem may decrease valproic acid levels below the therapeutic range, increasing the risk of seizures. Co-administration is generally not recommended.
Oral anticoagulants
Concurrent use with meropenem may enhance the anticoagulant effect of warfarin and other oral anticoagulants.
Storage
Store below 25°C. Protect from light and moisture. Reconstituted solutions should be used immediately or stored as per manufacturer's instructions, usually for a limited period under refrigeration.
Overdose
Limited experience with meropenem overdose. In the event of an overdose, discontinue meropenem and initiate general supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Meropenem should be used during pregnancy only if clearly needed and after careful risk-benefit assessment by a physician. It is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to the product packaging for exact expiry date.
Availability
Available in hospitals and pharmacies
Approval Status
Approved (DGDA, Bangladesh)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Meropenem is a well-established antibiotic with extensive clinical trial data supporting its efficacy and safety across various severe bacterial infections. Numerous studies have confirmed its broad-spectrum activity and favorable safety profile.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) periodically, especially in patients with pre-existing renal impairment.
- Liver function tests (e.g., ALT, AST) in patients receiving prolonged therapy.
- Complete Blood Count (CBC) with differential, especially during prolonged treatment.
Doctor Notes
- Empiric therapy with meropenem should be initiated after considering local epidemiological data and resistance patterns.
- Close monitoring of renal function is crucial, especially in critically ill patients and those with pre-existing renal impairment, for appropriate dose adjustments.
- Caution is advised in patients with a history of seizure disorders, as carbapenems may lower the seizure threshold.
- Perform susceptibility testing to confirm appropriate antimicrobial coverage.
Patient Guidelines
- Complete the entire course of treatment as prescribed by your doctor, even if you start to feel better.
- Report any new or worsening side effects to your healthcare provider immediately.
- Inform your doctor about all other medications, supplements, or herbal products you are taking.
- Do not share this medication with others or use it for conditions for which it was not prescribed.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to compensate for a missed one.
Driving Precautions
Cispenam may cause adverse effects such as dizziness or seizures, which could impair the ability to drive or operate machinery. Patients should be advised to exercise caution until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration during treatment.
- Follow a balanced diet and rest as needed to support recovery.
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