Citazar
Generic Name
Citicoline 500 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| citazar 500 mg tablet | ৳ 30.00 | ৳ 150.00 |
Description
Overview of the medicine
Citazar 500 mg Tablet contains Citicoline, a nootropic drug used to improve brain function and support nerve cell health. It is often prescribed for conditions involving cognitive impairment and neurological disorders.
Uses & Indications
Dosage
Adults
500 mg - 2000 mg daily, divided into 1-2 doses, depending on the indication and severity. For acute ischemic stroke, 1000 mg - 2000 mg daily for 6 weeks.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with pre-existing conditions.
Renal_impairment
No dose adjustment appears necessary as it is minimally eliminated renally.
How to Take
Take the tablet orally with or without food, as directed by your physician. Do not crush or chew the tablet.
Mechanism of Action
Citicoline enhances the synthesis of phosphatidylcholine, a major component of neuronal membranes. It also increases levels of several neurotransmitters, including acetylcholine, dopamine, and norepinephrine, and has neuroprotective effects by reducing free radical damage and inhibiting phospholipase A2.
Pharmacokinetics
Onset
Effects may be observed within hours to days for some acute conditions, but cognitive benefits may take weeks.
Excretion
Mainly excreted as carbon dioxide via respiration (approx. 80%) and via urine (approx. 15%).
Half life
Biphasic elimination with a half-life of 2-3 hours for the first phase and 20-30 hours for the second phase (metabolites).
Absorption
Well absorbed after oral administration, with bioavailability close to 100%.
Metabolism
Metabolized in the gut wall and liver to choline and cytidine.
Side Effects
Contraindications
- Hypersensitivity to Citicoline or any excipients
- Patients with hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa
Citicoline may enhance the effects of levodopa.
Meclofenoxate
Avoid concomitant administration with meclofenoxate.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Citicoline has low toxicity. In case of overdose, symptomatic and supportive measures should be taken. No specific antidote is known.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation is not recommended unless clearly necessary and benefits outweigh risks. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Citicoline or any excipients
- Patients with hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa
Citicoline may enhance the effects of levodopa.
Meclofenoxate
Avoid concomitant administration with meclofenoxate.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Citicoline has low toxicity. In case of overdose, symptomatic and supportive measures should be taken. No specific antidote is known.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation is not recommended unless clearly necessary and benefits outweigh risks. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved (General status for well-established drugs)
Patent Status
Generic available
Clinical Trials
Citicoline has been extensively studied in various clinical trials for its efficacy in stroke, cognitive impairment, and other neurological conditions. Evidence supports its role as a neuroprotectant and cognitive enhancer.
Lab Monitoring
- Routine monitoring of liver function tests may be considered in patients with pre-existing hepatic impairment, although Citicoline is generally well-tolerated.
Doctor Notes
- Emphasize patient compliance for optimal outcomes in chronic conditions.
- Advise patients to report any unusual side effects promptly.
- Consider concomitant therapy carefully, especially with levodopa.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medicines you are taking, including herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Citicoline is generally not known to affect the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain a healthy lifestyle with a balanced diet and regular exercise.
- Avoid smoking and excessive alcohol consumption.
- Engage in mentally stimulating activities to support cognitive health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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