Clobecort
Generic Name
Clobetasol Propionate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clobecort 005 cream | ৳ 75.00 | N/A |
| clobecort 005 ointment | ৳ 75.00 | N/A |
Description
Overview of the medicine
Clobecort is a potent topical corticosteroid used to treat various inflammatory skin conditions such as psoriasis, eczema, and lichen planus, offering anti-inflammatory, antipruritic, and vasoconstrictive effects.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily. Treatment should be limited to 2-4 weeks. Do not use more than 50g per week.
Elderly
Use with caution. Similar dosage to adults, but consider increased skin fragility and potential for increased systemic absorption.
Renal_impairment
No specific dosage adjustment is usually required for topical application.
How to Take
For external use only. Apply a thin film to the affected skin and gently rub in. Do not apply to the face, groin, or axillae unless directed by a doctor. Wash hands thoroughly after application.
Mechanism of Action
Clobetasol propionate works by activating naturally occurring substances in the skin to reduce swelling, redness, and itching. It inhibits phospholipase A2, leading to decreased synthesis of inflammatory mediators like prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Rapid, typically within a few hours to days.
Excretion
Excreted primarily by the kidneys, with some excretion in the bile.
Half life
Not well-defined for topical application; systemic corticosteroids have varied half-lives (e.g., prednisolone ~2-3 hours).
Absorption
Systemic absorption occurs, especially through damaged skin, large surface areas, or with occlusive dressings. Absorption is higher in areas with thin skin (e.g., face, genitalia).
Metabolism
Primarily metabolized in the liver, similar to other corticosteroids.
Side Effects
Contraindications
- Hypersensitivity to clobetasol propionate or any component of the formulation
- Untreated cutaneous infections (bacterial, fungal, viral, parasitic)
- Acne vulgaris, rosacea, perioral dermatitis
- Pruritus without inflammation
- Perianal and genital pruritus
Drug Interactions
0
CYP3A4 inhibitors (e.g., ritonavir, itraconazole) can increase systemic exposure to corticosteroids and lead to Cushing's syndrome and/or adrenal suppression. Use with caution.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the tube tightly closed.
Overdose
Acute overdose is unlikely. Chronic overdose or misuse may lead to hypercorticism (Cushing's syndrome) and adrenal suppression. Treatment involves gradual withdrawal under medical supervision and symptomatic management.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if topical clobetasol is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to clobetasol propionate or any component of the formulation
- Untreated cutaneous infections (bacterial, fungal, viral, parasitic)
- Acne vulgaris, rosacea, perioral dermatitis
- Pruritus without inflammation
- Perianal and genital pruritus
Drug Interactions
0
CYP3A4 inhibitors (e.g., ritonavir, itraconazole) can increase systemic exposure to corticosteroids and lead to Cushing's syndrome and/or adrenal suppression. Use with caution.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the tube tightly closed.
Overdose
Acute overdose is unlikely. Chronic overdose or misuse may lead to hypercorticism (Cushing's syndrome) and adrenal suppression. Treatment involves gradual withdrawal under medical supervision and symptomatic management.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if topical clobetasol is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check specific packaging for details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Numerous clinical trials have established the efficacy and safety of clobetasol propionate for severe inflammatory dermatoses. Ongoing research explores its use in specific populations or novel formulations.
Lab Monitoring
- Adrenal function tests (e.g., plasma cortisol, ACTH stimulation test) may be considered if systemic absorption is suspected, especially in pediatric patients or with extensive/prolonged use.
Doctor Notes
- Clobetasol propionate is a very potent corticosteroid; prescribe with caution, especially for prolonged use or on sensitive skin areas.
- Educate patients about proper application techniques, duration of use, and potential side effects to minimize risks.
Patient Guidelines
- Do not use for more than 4 weeks without medical advice.
- Avoid use on the face, groin, or axillae unless specifically instructed by a doctor.
- Do not use occlusive dressings (bandages or wraps) over the treated area.
- Avoid contact with eyes and mucous membranes.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Driving Precautions
Clobecort topical cream/ointment is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene and moisturize regularly to support skin barrier function.
- Avoid known irritants or allergens that may worsen your skin condition.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Clobecort Brand
Other medicines available under the same brand name
