Administer by deep intramuscular injection or by slow intravenous injection (over 3-4 minutes) or by intravenous infusion. Reconstitute with sterile water for injection according to package instructions.

Cloxacillin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located in the bacterial cell wall. This binding prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.

• •Known hypersensitivity to cloxacillin, other penicillins, or any component of the formulation.
• •History of severe allergic reactions to any beta-lactam antibiotic (e.g., anaphylaxis, Stevens-Johnson syndrome).

Store dry powder vials at room temperature (below 30°C) and protect from moisture. Do not freeze. Store reconstituted solution as per manufacturer's guidelines, typically refrigerated.

Symptoms of overdose may include nausea, vomiting, diarrhea, and electrolyte imbalance. In rare cases, neurological effects (e.g., seizures) may occur with very high doses, particularly in patients with renal impairment. Management is symptomatic and supportive. Hemodialysis may be effective in removing cloxacillin from circulation.

Pregnancy Category B. Studies in animals have not shown a risk, but human studies are not adequate. Use only if clearly needed. Cloxacillin is excreted in breast milk; use with caution in nursing mothers.