Co-Axet
Generic Name
Cefuroxime Axetil 500 mg + Clavulanic Acid 125 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| co axet 500 mg tablet | ৳ 55.00 | ৳ 220.00 |
Description
Overview of the medicine
Co-Axet 500 mg Tablet is a combination antibiotic containing Cefuroxime Axetil and Clavulanic Acid. Cefuroxime is a broad-spectrum cephalosporin antibiotic that fights bacteria. Clavulanic acid is a beta-lactamase inhibitor that prevents bacteria from destroying cefuroxime, thereby extending its antibacterial spectrum. It is used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
The usual adult dose is one Co-Axet 500 mg tablet (Cefuroxime 500 mg / Clavulanic Acid 125 mg) twice daily for 7-10 days, depending on the severity and type of infection.
Elderly
No specific dose reduction is required unless there is significant renal impairment.
Renal_impairment
Dosage adjustment is necessary for patients with impaired renal function. For creatinine clearance 10-29 mL/min, administer one Co-Axet 500 mg tablet every 24 hours. For creatinine clearance <10 mL/min, administer one Co-Axet 500 mg tablet every 48 hours. Patients on hemodialysis should receive an additional dose after each dialysis session.
How to Take
Take Co-Axet 500 mg Tablet orally, preferably with food, to enhance absorption and reduce potential gastrointestinal discomfort. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Clavulanic acid, a beta-lactamase inhibitor, binds irreversibly to beta-lactamase enzymes produced by some bacteria, preventing the enzymatic degradation of cefuroxime and broadening its spectrum of activity.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 2-3 hours after oral administration.
Excretion
Both cefuroxime and clavulanic acid are primarily excreted unchanged in the urine, via glomerular filtration and tubular secretion.
Half life
Cefuroxime: Approximately 1-1.5 hours. Clavulanic acid: Approximately 1 hour.
Absorption
Cefuroxime axetil is well absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime. Oral bioavailability is approximately 37-52%. Clavulanic acid is also well absorbed. Absorption is enhanced when taken with food.
Metabolism
Cefuroxime is not extensively metabolized. Clavulanic acid is extensively metabolized to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to cefuroxime, clavulanic acid, any other cephalosporins, penicillins, or any component of the formulation.
- •History of jaundice/hepatic dysfunction associated with previous use of cefuroxime/clavulanic acid combination.
Drug Interactions
Probenecid
Concomitant use with probenecid increases and prolongs the plasma concentration of cefuroxime.
Oral Anticoagulants
May enhance the anticoagulant effect of warfarin and other oral anticoagulants. INR monitoring is recommended.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; additional non-hormonal contraception may be advisable.
Antacids/H2-blockers/PPIs
Drugs that reduce gastric acidity (e.g., antacids, H2-blockers, proton pump inhibitors) may decrease the bioavailability of cefuroxime axetil and should not be used concomitantly.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. In rare cases, convulsions have been reported. Management is symptomatic and supportive. Hemodialysis can effectively remove cefuroxime and clavulanic acid from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Cefuroxime is excreted in small amounts into breast milk. Caution should be exercised when Co-Axet is administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer's specifications.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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