Adults

For iron deficiency anemia: 5-10 ml (50-100 mg elemental iron) once or twice daily, or as directed by the physician. For latent iron deficiency: 2.5-5 ml (25-50 mg elemental iron) daily.

Elderly

Similar to adult dosage. Caution should be exercised in elderly patients with existing comorbidities or on multiple medications.

Renal_impairment

No specific dosage adjustment is typically required, but monitoring of iron status is advisable.

Onset

Therapeutic effects are gradual, typically observed within a few weeks to months, as hemoglobin levels slowly rise.

Excretion

Excretion of absorbed iron is minimal and occurs primarily through desquamation of mucosal cells, sweat, urine, and bile.

Half life

The concept of a traditional half-life is not directly applicable to elemental iron as it is incorporated into physiological processes. Iron is recycled in the body.

Absorption

Iron Polymaltose Complex is absorbed through an active absorption mechanism in the intestinal mucosa, primarily in the duodenum and jejunum. Absorption is controlled and less affected by food or other substances compared to simple iron salts.

Metabolism

Absorbed iron is transported to the bone marrow for erythropoiesis (red blood cell formation), or stored as ferritin or hemosiderin in the liver, spleen, and bone marrow.

Vitamin C

Ascorbic acid (Vitamin C) can enhance iron absorption.

Antacids & PPIs

Antacids and proton pump inhibitors may reduce iron absorption. Separate administration by several hours.

Tetracyclines & Quinolones

Iron may reduce the absorption of tetracyclines and quinolones. Administer iron at least 2 hours before or after these antibiotics.