Congenil
Generic Name
Xylometazoline Hydrochloride 0.025% Nasal Drop
Manufacturer
Reputable Pharmaceutical Manufacturer
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| congenil 0025 nasal drop | ৳ 40.00 | N/A |
Description
Overview of the medicine
Congenil 0.025% Nasal Drop contains Xylometazoline Hydrochloride, a sympathomimetic agent that provides rapid and prolonged relief from nasal congestion. It works by constricting blood vessels in the nasal passages, reducing swelling and opening the airways. This strength is typically suitable for children.
Uses & Indications
Dosage
Adults
This 0.025% strength is primarily for pediatric use (children 2-12 years). For adults, typically 0.05% or 0.1% solutions are used. Children 2-12 years: 1-2 drops into each nostril 1-2 times daily, not exceeding 3 days.
Elderly
Use with caution; consult a physician. No specific dosage recommendations for 0.025% strength in elderly; adult strengths would be prescribed if appropriate.
Renal_impairment
No specific dosage adjustment required for topical nasal application due to minimal systemic absorption.
How to Take
For nasal use only. Blow nose gently before use. Tilt head back, apply drops into each nostril, and keep head tilted for a short while. Do not use for more than 3-5 consecutive days to avoid rebound congestion.
Mechanism of Action
Xylometazoline is an alpha-adrenergic agonist. It acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa, causing vasoconstriction. This reduces blood flow to the area, decreases swelling and congestion, thereby improving airflow.
Pharmacokinetics
Onset
Within 5-10 minutes
Excretion
Mainly via urine for systemically absorbed drug.
Half life
Approximately 5-6 hours (systemic)
Absorption
Minimal systemic absorption following topical nasal administration.
Metabolism
Primarily hepatic metabolism for absorbed portion.
Side Effects
Contraindications
- Hypersensitivity to xylometazoline or any component
- Transsphenoidal hypophysectomy or other surgery exposing the dura mater
- Narrow-angle glaucoma
- Rhinitis sicca or atrophic rhinitis
- Children under 2 years of age (for 0.025% strength)
Drug Interactions
MAO inhibitors
Concurrent use may potentiate the pressor effects of xylometazoline, leading to hypertensive crisis.
Tricyclic antidepressants
May increase the risk of cardiovascular effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include severe dizziness, sweating, headache, slow pulse, high blood pressure (followed by low blood pressure), and coma. In children, CNS depression, sedation, and coma are more likely. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation should only be done if clearly necessary and after consulting a doctor, as data is limited. Use with caution.
Side Effects
Contraindications
- Hypersensitivity to xylometazoline or any component
- Transsphenoidal hypophysectomy or other surgery exposing the dura mater
- Narrow-angle glaucoma
- Rhinitis sicca or atrophic rhinitis
- Children under 2 years of age (for 0.025% strength)
Drug Interactions
MAO inhibitors
Concurrent use may potentiate the pressor effects of xylometazoline, leading to hypertensive crisis.
Tricyclic antidepressants
May increase the risk of cardiovascular effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include severe dizziness, sweating, headache, slow pulse, high blood pressure (followed by low blood pressure), and coma. In children, CNS depression, sedation, and coma are more likely. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation should only be done if clearly necessary and after consulting a doctor, as data is limited. Use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date; check product label for specific expiry.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
Clinical Trials
Xylometazoline has been extensively studied for its efficacy and safety in treating nasal congestion. Studies confirm its rapid onset and sustained action.
Lab Monitoring
- No specific lab monitoring is required for topical xylometazoline.
Doctor Notes
- Emphasize the importance of not exceeding the recommended duration of use (3-5 days) to prevent rhinitis medicamentosa.
- Advise patients on proper administration technique to maximize efficacy and minimize systemic absorption.
Patient Guidelines
- Do not use for more than 3-5 consecutive days to avoid rebound congestion.
- Avoid getting the drops in your eyes or mouth.
- If symptoms persist beyond 7 days, consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
Driving Precautions
Xylometazoline nasal drops are not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Stay hydrated to help thin mucus.
- Avoid allergens that trigger nasal congestion.
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