Cordef
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cordef 24 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Cordef 24 mg tablet contains Deflazacort, a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, as well as Duchenne muscular dystrophy. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition. For Duchenne Muscular Dystrophy, typically 0.9 mg/kg/day orally. For other conditions, initial dose may range from 6 mg to 18 mg per day, adjusted based on response. Cordef 24 mg is a higher strength, likely for severe conditions or specific loading doses.
Elderly
No specific dose adjustments required based on age alone, but caution with comorbidities. Use the lowest effective dose.
Renal_impairment
No specific dose adjustment recommended for mild to moderate renal impairment. For severe impairment, monitor for adverse effects.
How to Take
Take orally, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels. Do not stop suddenly without consulting a doctor due to risk of withdrawal symptoms.
Mechanism of Action
Deflazacort acts as a glucocorticoid, binding to specific intracellular glucocorticoid receptors. This complex then translocates into the nucleus, modulating gene expression. It inhibits the release of various inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppresses the immune response by affecting lymphocyte function and migration.
Pharmacokinetics
Onset
Rapid, typically within hours for anti-inflammatory effects.
Excretion
Primarily excreted in the urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
The active metabolite has a plasma half-life of approximately 1.5-2 hours.
Absorption
Well absorbed from the gastrointestinal tract, rapidly converted to its active metabolite (21-desacetyl deflazacort).
Metabolism
Rapidly metabolized in the liver to the active metabolite, 21-desacetyl deflazacort, which is then further metabolized.
Side Effects
Contraindications
- Hypersensitivity to Deflazacort or any component of the formulation
- Systemic fungal infections
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses
Drug Interactions
Warfarin
May alter anticoagulant effect; monitor INR.
Live vaccines
Avoid during immunosuppressive therapy.
Ketoconazole, Erythromycin
May increase Deflazacort levels by inhibiting liver enzymes.
Diuretics (thiazide and loop)
Increased risk of hypokalemia.
Phenytoin, Phenobarbital, Rifampicin
May decrease Deflazacort levels by inducing liver enzymes.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects such as fluid retention, hyperglycemia, and adrenal suppression with chronic use. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Corticosteroids are excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Deflazacort or any component of the formulation
- Systemic fungal infections
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses
Drug Interactions
Warfarin
May alter anticoagulant effect; monitor INR.
Live vaccines
Avoid during immunosuppressive therapy.
Ketoconazole, Erythromycin
May increase Deflazacort levels by inhibiting liver enzymes.
Diuretics (thiazide and loop)
Increased risk of hypokalemia.
Phenytoin, Phenobarbital, Rifampicin
May decrease Deflazacort levels by inducing liver enzymes.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects such as fluid retention, hyperglycemia, and adrenal suppression with chronic use. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Corticosteroids are excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check specific packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of Deflazacort in various inflammatory and autoimmune disorders, particularly in Duchenne muscular dystrophy, where it has shown benefits in motor function and survival.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Electrolyte levels (especially potassium)
- Bone density (for long-term use)
- Ophthalmological exams (for long-term use)
- Growth monitoring in children
Doctor Notes
- Consider lower doses or alternate day therapy if possible for long-term use to minimize adverse effects.
- Monitor patients closely for signs of infection, especially atypical presentations, due to immunosuppression.
- Educate patients on the importance of not discontinuing the drug abruptly.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medication abruptly without consulting your doctor.
- Report any signs of infection, unusual bruising or bleeding, or mood changes to your doctor.
- Carry a steroid treatment card if you are on long-term therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Deflazacort generally does not impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or vision changes, avoid these activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to manage fluid retention and blood pressure.
- Engage in regular, moderate exercise if appropriate and approved by your doctor.
- Avoid contact with people who have infections, especially chickenpox or measles.
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