Cordef
Generic Name
Dexamethasone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cordef 6 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Cordef 6 mg Tablet contains Dexamethasone, a potent synthetic corticosteroid. It is used to treat a wide range of inflammatory and autoimmune conditions, allergic reactions, and certain types of cancer.
Uses & Indications
Dosage
Adults
Initial dose typically 0.5-9 mg daily, divided, depending on condition. Maintenance dose varies.
Elderly
No specific dosage adjustment usually required, but use with caution due to increased risk of side effects.
Renal_impairment
No dosage adjustment needed for renal impairment, as it is primarily metabolized by the liver.
How to Take
Take orally with food or milk to minimize gastrointestinal irritation. Do not stop suddenly; dosage should be tapered.
Mechanism of Action
Dexamethasone acts as a glucocorticoid receptor agonist. It inhibits inflammatory mediators like prostaglandins and leukotrienes, suppresses immune responses, and alters protein synthesis.
Pharmacokinetics
Onset
Oral: 1-2 hours for anti-inflammatory effects.
Excretion
Mainly renal, as inactive metabolites.
Half life
Plasma half-life: 3-4.5 hours; Biological half-life: 36-72 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily hepatic, by cytochrome P450 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Dexamethasone or any component
- Live virus vaccines (when on immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Warfarin
May alter anticoagulant effect.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Phenytoin, Carbamazepine, Rifampicin
May decrease Dexamethasone levels.
Storage
Store in a cool, dry place, away from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Acute overdose is rare and usually not life-threatening. Management involves supportive care and symptomatic treatment. Chronic overdose leads to Cushing's syndrome.
Pregnancy & Lactation
Use only if potential benefit outweighs risk. Dexamethasone can cross the placenta and is excreted in breast milk. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Dexamethasone or any component
- Live virus vaccines (when on immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Warfarin
May alter anticoagulant effect.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Phenytoin, Carbamazepine, Rifampicin
May decrease Dexamethasone levels.
Storage
Store in a cool, dry place, away from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Acute overdose is rare and usually not life-threatening. Management involves supportive care and symptomatic treatment. Chronic overdose leads to Cushing's syndrome.
Pregnancy & Lactation
Use only if potential benefit outweighs risk. Dexamethasone can cross the placenta and is excreted in breast milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA and international regulatory bodies
Patent Status
Generic available (off-patent)
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory, allergic, and autoimmune conditions, including its role in COVID-19 management.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (long-term use)
Doctor Notes
- Advise patients on gradual withdrawal to avoid adrenal crisis.
- Monitor blood glucose, electrolytes, and bone density during prolonged therapy.
- Caution in patients with diabetes, hypertension, and osteoporosis.
- Consider gastric protection with long-term high-dose use.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor.
- Take with food or milk to prevent stomach upset.
- Report any unusual side effects to your doctor.
- Avoid exposure to infections if on high doses.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Dexamethasone may cause dizziness, vision changes, or fatigue in some individuals. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise.
- Monitor blood sugar and blood pressure regularly.
- Avoid alcohol and smoking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Cordef Brand
Other medicines available under the same brand name
