Coxetori
Generic Name
Etoricoxib
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| coxetori 60 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Coxetori 60 mg Tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor NSAID. It is used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis, Ankylosing Spondylitis: 60 mg once daily. Acute Pain (including dental pain): 60 mg once daily, maximum 7 days. Acute Gouty Arthritis: 120 mg once daily for a maximum of 8 days.
Elderly
No dosage adjustment generally required, but caution is advised due to increased risk of adverse effects.
Renal_impairment
For mild to moderate renal impairment (CrCl 30-80 mL/min), no dose adjustment. Not recommended for severe renal impairment (CrCl <30 mL/min).
How to Take
Take orally, with or without food. Swallow the tablet whole with a glass of water. Do not chew or crush.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), which is responsible for the synthesis of prostaglandins involved in pain, inflammation, and fever. By inhibiting COX-2, it reduces prostaglandin production, thereby alleviating pain and inflammation, while minimizing gastrointestinal side effects associated with non-selective NSAIDs.
Pharmacokinetics
Onset
Onset of action within 24 minutes for acute pain, with sustained effect; for chronic conditions, therapeutic effects may be observed within a few days.
Excretion
Excreted primarily through the kidneys (approximately 70%) and in feces (approximately 20%) as metabolites.
Half life
Elimination half-life is approximately 22 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved in approximately 1 hour. Oral bioavailability is about 100%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (mainly CYP3A4), to inactive hydroxylated metabolites.
Side Effects
Contraindications
- •Hypersensitivity to etoricoxib or any component of the tablet
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic or renal impairment
- •Congestive heart failure (NYHA II-IV)
- •Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Uncontrolled hypertension
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Warfarin
May increase the anticoagulant effect, leading to increased risk of bleeding.
Methotrexate
May increase plasma methotrexate levels, leading to increased toxicity.
ACE Inhibitors/ARBs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Oral Contraceptives
May increase plasma concentrations of ethinyl estradiol, potentially increasing the risk of adverse effects associated with oral contraceptives.
Diuretics (e.g., Furosemide)
May reduce the natriuretic effect of diuretics.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care should be initiated. There is no specific antidote. Hemodialysis is unlikely to remove etoricoxib effectively.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters. Etoricoxib is excreted in breast milk, so it should be avoided during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in retail pharmacies
Approval Status
Approved by regulatory authorities (e.g., DGDA, EMA)
Patent Status
Patents expired, generic versions available
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Global Brand Names
International brand names for this medicine
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