Cpzith
Generic Name
Azithromycin
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cpzith 200 mg suspension | ৳ 128.00 | N/A |
Description
Overview of the medicine
Cpzith 200 mg Suspension is an antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days. (Suspension dosage for children varies by weight and infection type, refer to prescribing info.)
Elderly
No specific dose adjustment is needed unless severe renal or hepatic impairment.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution with severe impairment.
How to Take
Administer orally, with or without food. Shake well before use. Use the provided measuring device for accurate dosing.
Mechanism of Action
Azithromycin works by inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translocation of peptides.
Pharmacokinetics
Onset
Peak plasma concentrations are reached within 2-3 hours.
Excretion
Primarily excreted unchanged in bile; a small portion is excreted in urine.
Half life
Terminal half-life is 2-4 days.
Absorption
Well absorbed from the gastrointestinal tract, bioavailability is approximately 37%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations, monitor for side effects.
Antacids (containing aluminum or magnesium)
Decreased absorption of azithromycin; administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store at room temperature (15-30°C) or refrigerated (2-8°C) as per manufacturer's instructions, do not freeze.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations, monitor for side effects.
Antacids (containing aluminum or magnesium)
Decreased absorption of azithromycin; administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store at room temperature (15-30°C) or refrigerated (2-8°C) as per manufacturer's instructions, do not freeze.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for unopened product. After reconstitution, generally stable for 5-10 days (refer to specific product label for exact duration and storage conditions).
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generics available (patent expired for original drug)
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across a wide range of bacterial infections. Trials have confirmed its short-course therapy benefits.
Lab Monitoring
- Liver function tests in patients with pre-existing hepatic impairment.
- Monitor INR if co-administered with warfarin.
Doctor Notes
- Emphasize adherence to the full prescribed course to minimize resistance development.
- Counsel parents/caregivers on proper measurement and administration techniques for pediatric suspension.
- Be aware of potential for QT prolongation in susceptible patients, especially with co-medications.
- Monitor for signs of C. difficile-associated diarrhea post-antibiotic treatment.
Patient Guidelines
- Complete the full course of antibiotic treatment even if symptoms improve.
- Shake the suspension well before each use.
- Store at room temperature as directed.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; advise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent the spread of infection.
- Avoid close contact with sick individuals.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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