CVnor-A
Generic Name
Amlodipine + Atorvastatin
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cvnor a 5 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
CVnor-A is a combination medication containing Amlodipine, a calcium channel blocker, and Atorvastatin, an HMG-CoA reductase inhibitor. It is used to treat high blood pressure and high cholesterol, reducing the risk of cardiovascular events.
Uses & Indications
Dosage
Adults
Usually one tablet once daily. Dosage may be adjusted based on individual response and tolerability. Max Amlodipine 10mg, Atorvastatin 80mg.
Elderly
No specific dose adjustment for Amlodipine; caution with Atorvastatin, start with lower doses.
Renal_impairment
No dose adjustment for Amlodipine; for Atorvastatin, no dose adjustment in mild to moderate impairment, use with caution in severe.
How to Take
Take orally, once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Amlodipine relaxes blood vessels, improving blood flow and lowering blood pressure. Atorvastatin reduces the production of cholesterol in the liver, lowering 'bad' cholesterol (LDL) and triglycerides and increasing 'good' cholesterol (HDL).
Pharmacokinetics
Onset
Amlodipine: 6-12 hours for antihypertensive effect. Atorvastatin: Cholesterol reduction within 2 weeks.
Excretion
Amlodipine: Primarily renal (60% as metabolites). Atorvastatin: Primarily biliary/fecal.
Half life
Amlodipine: 30-50 hours. Atorvastatin: Parent drug 14 hours (active metabolites longer).
Absorption
Amlodipine: Slowly and almost completely absorbed. Atorvastatin: Rapidly absorbed.
Metabolism
Amlodipine: Extensive hepatic metabolism to inactive metabolites. Atorvastatin: Extensively metabolized by CYP3A4 to active and inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Amlodipine, Atorvastatin, or any excipients.
- •Active liver disease or unexplained persistent elevations of serum transaminases.
- •Pregnancy and lactation.
Drug Interactions
Diltiazem
May increase plasma concentrations of Amlodipine.
Grapefruit juice
Increases plasma concentrations of atorvastatin.
Simvastatin, Ezetimibe
Increased risk of myopathy/rhabdomyolysis when co-administered with Atorvastatin.
Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)
Increased plasma concentrations of atorvastatin, increasing risk of myopathy/rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include excessive vasodilation with peripheral hypotension and reflex tachycardia. Management involves symptomatic treatment and supportive measures. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
