Cynomin
Generic Name
Cyanocobalamin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cynomin 250 mcg injection | ৳ 4.51 | N/A |
| cynomin 1000 mcg injection | ৳ 5.02 | N/A |
Description
Overview of the medicine
Cynomin is a brand of Cyanocobalamin, a synthetic form of Vitamin B12. It is essential for nerve tissue health, brain function, DNA synthesis, and the production of red blood cells. It is used to prevent and treat vitamin B12 deficiency.
Uses & Indications
Dosage
Adults
For deficiency: 500-1000 mcg daily orally, or as directed by a physician. For maintenance: 1000 mcg daily or weekly depending on severity.
Elderly
Same as adults, but monitor for absorption issues and potential drug interactions.
Renal_impairment
No specific dose adjustment usually needed, as it is water-soluble and excess is excreted renally. Use with caution in severe impairment.
How to Take
Oral tablets can be taken with or without food. Sublingual tablets should dissolve under the tongue. Injections are administered intramuscularly by a healthcare professional.
Mechanism of Action
Cyanocobalamin is converted in the body to its active coenzyme forms, methylcobalamin and 5-deoxyadenosylcobalamin. These active forms are crucial for several metabolic processes, including DNA synthesis, fatty acid metabolism, and amino acid metabolism, playing a vital role in red blood cell formation and neurological function.
Pharmacokinetics
Onset
Gradual; improvement in symptoms of deficiency over weeks to months.
Excretion
Primarily renal excretion of unbound B12; also undergoes enterohepatic recirculation.
Half life
Approximately 6 days in plasma, but storage in the liver is significant, allowing for prolonged effects.
Absorption
Absorbed in the ileum via intrinsic factor, with a small amount absorbed by passive diffusion.
Metabolism
Converted to active coenzymes (methylcobalamin and 5-deoxyadenosylcobalamin); the cobalamin nucleus itself undergoes minimal metabolism.
Side Effects
Contraindications
- •Hypersensitivity to cyanocobalamin or cobalt
- •Leber's disease (hereditary optic nerve atrophy)
Drug Interactions
Metformin
May decrease Vitamin B12 absorption. Supplementation may be required, especially with long-term use.
Chloramphenicol
May antagonize the hematologic response to B12 therapy, especially in pernicious anemia.
H2-receptor blockers (e.g., Ranitidine)
Similar to PPIs, can reduce B12 absorption by decreasing stomach acid.
Proton Pump Inhibitors (e.g., Omeprazole)
May reduce gastric acid production, impairing B12 absorption over long-term use.
Storage
Store below 30°C (86°F) in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Vitamin B12 is water-soluble, and excessive doses are usually excreted in the urine. It is generally considered non-toxic, even at very high doses. Symptomatic and supportive treatment if any unexpected adverse effects occur.
Pregnancy & Lactation
Vitamin B12 is essential during pregnancy and lactation for proper fetal and infant development. It is generally considered safe when taken in recommended doses. Consult your doctor for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, as indicated on the packaging.
Availability
Available in pharmacies and drugstores nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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