D-Cort
Generic Name
Dexamethasone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d cort 05 mg tablet | ৳ 0.86 | ৳ 8.60 |
Description
Overview of the medicine
D-Cort 0.5 mg Tablet contains Dexamethasone, a potent synthetic corticosteroid used for its anti-inflammatory and immunosuppressive effects. It is used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Typical starting dose for various conditions ranges from 0.5 mg to 9 mg daily, divided into 2-4 doses. Dosage must be individualized based on the disease and patient response.
Elderly
Lower doses may be considered due to potential for increased adverse effects and comorbidities. Careful monitoring is advised.
Renal_impairment
No specific dosage adjustment is generally required, but caution is advised in severe cases due to altered fluid balance.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it unless specifically instructed by a doctor.
Mechanism of Action
Dexamethasone works by binding to glucocorticoid receptors, inhibiting the release of inflammatory mediators like prostaglandins and leukotrienes, and suppressing the immune system by reducing the activity of lymphocytes and other immune cells.
Pharmacokinetics
Onset
Within hours of oral administration; peak effect around 1-2 hours.
Excretion
Mainly excreted in the urine as inactive metabolites.
Half life
Biological half-life is 36-54 hours (plasma half-life 3-4.5 hours).
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily hepatic (liver) metabolism.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Dexamethasone or any component of the formulation
- Live vaccine administration during high-dose corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., furosemide)
May increase potassium loss.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase dexamethasone levels.
CYP3A4 inducers (e.g., rifampin, phenytoin)
May decrease dexamethasone levels.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rarely life-threatening. Chronic overdose can lead to signs of hypercorticism (Cushing's syndrome). Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose suspected.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Dexamethasone can be excreted in breast milk; caution is advised, and breastfeeding mothers should consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Dexamethasone or any component of the formulation
- Live vaccine administration during high-dose corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., furosemide)
May increase potassium loss.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase dexamethasone levels.
CYP3A4 inducers (e.g., rifampin, phenytoin)
May decrease dexamethasone levels.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rarely life-threatening. Chronic overdose can lead to signs of hypercorticism (Cushing's syndrome). Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose suspected.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Dexamethasone can be excreted in breast milk; caution is advised, and breastfeeding mothers should consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, depending on specific manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, EMA, DGDA)
Patent Status
Generic (Off-patent)
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory, autoimmune, and oncological conditions. Recent trials also explored its role in COVID-19 management for severe cases.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmologic examination (for long-term use)
Doctor Notes
- Emphasize gradual tapering of dose to prevent adrenal crisis.
- Monitor patients for signs of infection, especially with prolonged use.
- Counsel patients on potential mood changes and bone health measures.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
- Inform your doctor about all other medications you are taking.
- Report any unusual side effects or worsening of your condition.
- Carry an identification card indicating you are on corticosteroid therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Dexamethasone may cause dizziness, vision changes, or mood disturbances in some individuals. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet to manage potential weight gain and blood sugar changes.
- Engage in regular, moderate exercise to support bone health.
- Avoid exposure to people with infections, especially chickenpox or measles, as your immune system may be suppressed.
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International brand names for this medicine. Click a brand to search for detailed information.
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