Danflex
Generic Name
Diclofenac Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| danflex 25 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Danflex 25 mg Capsule contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions such as arthritis, acute gout, and muscle aches.
Uses & Indications
Dosage
Adults
Usually 25-50 mg, 2-3 times daily, not exceeding 150 mg per day. The lowest effective dose for the shortest duration should be used.
Elderly
Lower initial doses are recommended, with careful monitoring due to increased risk of side effects.
Renal_impairment
Use with caution and at reduced doses. Monitor renal function closely. Avoid in severe renal impairment.
How to Take
Take the capsule whole with a glass of water, preferably with or after food, to minimize gastrointestinal upset. Do not chew or crush the capsule.
Mechanism of Action
Diclofenac Sodium works by inhibiting cyclo-oxygenase (COX) enzymes, COX-1 and COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By reducing prostaglandin production, diclofenac helps to alleviate these symptoms.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Approximately 60% is excreted in the urine as metabolites, and about 30-40% is excreted in bile as metabolites.
Half life
Plasma elimination half-life is approximately 1-2 hours.
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Extensively metabolized in the liver, primarily via hydroxylation and glucuronidation, mainly by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or any excipients
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of cerebrovascular bleeding or other active bleeding
Drug Interactions
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Diuretics and ACE inhibitors
Reduced effectiveness of these medications; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal side effects.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Treatment is supportive and symptomatic; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, changing to Category D in the third trimester. Avoid during the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; diclofenac passes into breast milk in small amounts.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or any excipients
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of cerebrovascular bleeding or other active bleeding
Drug Interactions
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Diuretics and ACE inhibitors
Reduced effectiveness of these medications; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal side effects.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Treatment is supportive and symptomatic; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, changing to Category D in the third trimester. Avoid during the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; diclofenac passes into breast milk in small amounts.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in pharmacies, hospitals and clinics
Approval Status
Approved for general use
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Diclofenac Sodium has been extensively studied in numerous clinical trials demonstrating its efficacy and safety profile for various pain and inflammatory conditions.
Lab Monitoring
- Complete Blood Count (CBC) with differential (especially for long-term use)
- Liver function tests (ALT, AST)
- Renal function tests (Creatinine, BUN)
- Fecal occult blood test (if gastrointestinal symptoms develop)
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration to minimize risks, especially in elderly patients or those with cardiovascular/GI risk factors.
- Assess renal and hepatic function before and during prolonged therapy.
- Advise patients about potential cardiovascular and GI adverse events and when to seek immediate medical attention.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Take with food or milk to reduce stomach upset.
- Report any unusual bleeding, persistent stomach pain, or black/tarry stools to your doctor immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated. Regular exercise, if appropriate for your condition, can also help manage pain. Avoid smoking.
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