danflex
Generic Name
Baclofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| danflex 50 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Danflex 50 mg capsule contains Baclofen, a muscle relaxant used to treat spasticity resulting from various conditions such as multiple sclerosis, spinal cord injuries, and cerebral palsy. It helps to reduce muscle tone, cramps, and involuntary spasms.
Uses & Indications
Dosage
Adults
Initial dose is usually 5 mg three times daily, gradually increasing by 5 mg increments every 3 days. Maximum recommended dose is 80 mg/day (40 mg three times daily). Danflex 50 mg capsule is typically used for maintenance once the optimal dose is identified.
Elderly
Lower initial doses and slower titration are recommended due to increased sensitivity and potential for adverse effects. Careful monitoring is advised.
Renal_impairment
Significant dose reduction is required. Initial dose should be 5 mg/day, adjusted cautiously based on clinical response and creatinine clearance.
How to Take
Take Danflex 50 mg capsule orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the capsule whole with water. Do not crush or chew.
Mechanism of Action
Baclofen acts as a GABA-B receptor agonist, primarily in the spinal cord. It inhibits both monosynaptic and polysynaptic reflex transmission, reducing the release of excitatory neurotransmitters. This leads to a decrease in muscle tone and a reduction in the frequency and severity of muscle spasms.
Pharmacokinetics
Onset
Onset of action typically occurs within 0.5-1 hour after oral administration.
Excretion
Mainly excreted unchanged by the kidneys (70-80%) within 72 hours, with a small amount excreted in feces.
Half life
Plasma elimination half-life is approximately 3-4 hours.
Absorption
Rapid and almost complete absorption from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Approximately 5-15% of the dose is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the formulation.
- Untreated epilepsy or seizure disorders (relative contraindication, use with extreme caution).
Drug Interactions
Antihypertensives
Additive hypotensive effects may occur.
Tricyclic Antidepressants (TCAs)
May potentiate the hypotensive effects of Baclofen.
Monoamine Oxidase Inhibitors (MAOIs)
Enhanced CNS depression; use with caution.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased sedation and respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, confusion, decreased breathing, muscle weakness, seizures, and coma. In case of overdose, seek immediate medical attention. Treatment is supportive, focusing on maintaining respiration and circulation.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; use with caution in nursing mothers, considering the potential risks to the infant versus the benefits to the mother.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the formulation.
- Untreated epilepsy or seizure disorders (relative contraindication, use with extreme caution).
Drug Interactions
Antihypertensives
Additive hypotensive effects may occur.
Tricyclic Antidepressants (TCAs)
May potentiate the hypotensive effects of Baclofen.
Monoamine Oxidase Inhibitors (MAOIs)
Enhanced CNS depression; use with caution.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased sedation and respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, confusion, decreased breathing, muscle weakness, seizures, and coma. In case of overdose, seek immediate medical attention. Treatment is supportive, focusing on maintaining respiration and circulation.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; use with caution in nursing mothers, considering the potential risks to the infant versus the benefits to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Baclofen for spasticity management. Ongoing post-marketing surveillance continues to monitor its long-term effects and rare adverse events.
Lab Monitoring
- Periodic monitoring of renal function, especially in patients with impaired kidney function.
- Liver function tests may be considered periodically during long-term therapy.
Doctor Notes
- Emphasize slow titration of Baclofen to achieve optimal therapeutic effect with minimal side effects.
- Educate patients about the importance of gradual withdrawal to prevent severe adverse reactions.
- Monitor for signs of CNS depression, especially when co-administered with other depressants.
Patient Guidelines
- Do not stop taking Danflex abruptly; doses must be reduced gradually.
- Avoid alcohol and other CNS depressants while on this medication.
- Report any severe side effects, especially unusual changes in mood or behavior, or increased muscle weakness.
- Take exactly as prescribed by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Danflex 50 mg capsule can cause drowsiness, dizziness, and blurred vision, which may impair your ability to drive or operate machinery safely. Exercise caution and avoid such activities if affected.
Lifestyle Advice
- Due to potential drowsiness and dizziness, avoid driving or operating heavy machinery until you know how this medicine affects you. Be cautious when performing activities requiring mental alertness.
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