Dapclin
Generic Name
Dapsone 7.5% Gel
Manufacturer
ABC Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dapclin 75 gel | ৳ 250.00 | N/A |
Description
Overview of the medicine
Dapclin 7.5% Gel contains dapsone and is used topically to treat inflammatory lesions of acne vulgaris. It helps to reduce redness and swelling associated with acne.
Uses & Indications
Dosage
Adults
Apply a thin layer to affected areas once daily. Rub in gently and completely.
Elderly
No specific dosage adjustment required. Use as per adult dosage.
Renal_impairment
No specific dosage adjustment required for topical use, as systemic absorption is minimal.
How to Take
For topical use only. Cleanse the skin thoroughly and pat dry before application. Apply a pea-sized amount to affected areas and rub in gently until absorbed. Wash hands after application.
Mechanism of Action
Dapsone is a sulfone antibiotic with anti-inflammatory and antibacterial properties. Its mechanism in acne involves inhibiting neutrophil chemotaxis, reducing inflammation, and possibly inhibiting the growth of *Cutibacterium acnes* (formerly *Propionibacterium acnes*).
Pharmacokinetics
Onset
Clinical improvement may be seen within 4-12 weeks of consistent daily use.
Excretion
Minimal topical excretion. Systemically, primarily renal excretion.
Half life
Not well characterized for topical application due to minimal systemic absorption; systemically, it's around 20-30 hours.
Absorption
Systemic absorption is minimal following topical application (approximately 1-2% of the applied dose).
Metabolism
Minimal topical metabolism. Systemically, metabolized in the liver, primarily via N-acetylation and N-hydroxylation.
Side Effects
Contraindications
- •Known hypersensitivity to dapsone or any other component of the gel.
Drug Interactions
Benzoyl Peroxide
Concomitant use with topical benzoyl peroxide may cause temporary yellow/orange skin discoloration at the application site.
Topical Sulfonamides
Potentially increased risk of hypersensitivity reactions with other sulfonamide-containing topical products.
Storage
Store at controlled room temperature (15°C to 30°C / 59°F to 86°F). Protect from direct light and moisture. Do not freeze. Keep the tube tightly closed when not in use.
Overdose
Overdose with topical application is unlikely due to minimal systemic absorption. In case of accidental ingestion, seek immediate medical attention.
Pregnancy & Lactation
Consult a doctor before use if pregnant or breastfeeding. Use only if the potential benefit justifies the potential risk to the fetus or infant. Dapsone is excreted into breast milk in small amounts; caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Refer to the expiry date on the packaging.
Availability
Pharmacies, Drugstores
Approval Status
FDA Approved
Patent Status
Patent expired for generic formulations
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Global Brand Names
International brand names for this medicine
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