Daxotel
Generic Name
Docetaxel
Manufacturer
Generic Manufacturer (e.g., Acme Pharmaceuticals)
Country
Varies by region and manufacturer
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daxotel 20 mg injection | ৳ 3,500.00 | N/A |
Description
Overview of the medicine
Daxotel 20 mg Injection contains Docetaxel, an antineoplastic agent belonging to the taxane family. It is used in chemotherapy to treat various types of cancer by interfering with cell division.
Uses & Indications
Dosage
Adults
Dosage varies significantly based on cancer type, treatment regimen, and patient condition (e.g., 60-100 mg/m² infused intravenously over 1 hour every 3 weeks). Administered under medical supervision.
Elderly
No specific dosage adjustment is generally required for elderly patients, but renal and hepatic function should be monitored.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. Data for severe renal impairment is limited.
How to Take
Administered as a 1-hour intravenous infusion. It must be diluted with an appropriate infusion solution (e.g., 5% dextrose or 0.9% sodium chloride) before administration. Premedication with corticosteroids is usually required to reduce hypersensitivity reactions and fluid retention.
Mechanism of Action
Docetaxel promotes the assembly of microtubules from tubulin dimers and inhibits their depolymerization, leading to an accumulation of stable microtubules. This prevents cells from progressing through mitosis, causing cell cycle arrest and inducing apoptosis in cancer cells.
Pharmacokinetics
Onset
Therapeutic effects are observed over the course of treatment, not as an immediate onset like analgesics.
Excretion
Mainly excreted in the feces (approximately 75% within 7 days, primarily as metabolites), with a small amount excreted in the urine (approximately 6% within 7 days).
Half life
Terminal elimination half-life is approximately 11-12 hours.
Absorption
Administered intravenously, resulting in 100% bioavailability. Plasma concentrations exhibit a triphasic decline after a short intravenous infusion.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) isoenzyme system.
Side Effects
Contraindications
- •Known severe hypersensitivity to docetaxel or polysorbate 80
- •Baseline neutrophil count <1500 cells/mm³
- •Severe hepatic impairment
- •Pregnancy and lactation
Drug Interactions
Other myelosuppressive drugs
May exacerbate bone marrow suppression.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
Can increase docetaxel plasma concentrations, potentially increasing toxicity.
CYP3A4 Inducers (e.g., phenytoin, carbamazepine, rifampicin)
Can decrease docetaxel plasma concentrations, potentially reducing efficacy.
Storage
Store unopened vials in a refrigerator (2°C - 8°C). Protect from light. Do not freeze. Refer to product leaflet for diluted solution storage.
Overdose
Symptoms of overdose include more pronounced bone marrow suppression, peripheral neurotoxicity, and mucositis. Management is symptomatic and supportive, including administration of granulocyte-colony stimulating factor (G-CSF) for myelosuppression.
Pregnancy & Lactation
Docetaxel is contraindicated during pregnancy due to potential fetal harm (Pregnancy Category D). Women of childbearing potential should use effective contraception. It is also contraindicated during lactation due to potential excretion into breast milk and harm to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored correctly (check specific product leaflet). Once diluted, it must be used immediately or within a specified timeframe (e.g., 6 hours).
Availability
Hospitals, specialized oncology clinics, pharmacies (with special handling)
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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