Daxotel
Generic Name
Docetaxel
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daxotel 80 mg injection | ৳ 10,000.00 | N/A |
Description
Overview of the medicine
Docetaxel is an antineoplastic agent belonging to the taxoid class. It is used in the treatment of various cancers, including breast cancer, non-small cell lung cancer, prostate cancer, gastric adenocarcinoma, and head and neck cancer. Daxotel 80 mg injection is administered intravenously by a healthcare professional.
Uses & Indications
Dosage
Adults
Dosage varies by indication and patient's body surface area (BSA) and may range from 75 mg/m² to 100 mg/m² given every three weeks. Premedication is usually required.
Elderly
No specific dose adjustments required solely based on age for patients with normal organ function. Close monitoring is recommended.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Data for severe impairment is limited; caution advised.
How to Take
Daxotel 80 mg is administered as a 1-hour intravenous infusion. It should be given by a healthcare professional experienced in the administration of cytotoxic agents. Premedication with corticosteroids is usually required to reduce hypersensitivity reactions and fluid retention.
Mechanism of Action
Docetaxel acts by promoting the assembly of microtubules from tubulin dimers and simultaneously inhibiting their depolymerization. This leads to the stabilization of microtubules, preventing normal mitotic and interphase cellular functions, ultimately resulting in cell cycle arrest and cell death.
Pharmacokinetics
Onset
Rapidly distributed after intravenous administration.
Excretion
Mainly excreted in feces (approximately 75%) as metabolites, with a small amount in urine (approximately 6%) as metabolites.
Half life
Alpha phase half-life: 4 min, Beta phase half-life: 36 min, Terminal phase half-life: 11.1 hours (range 4 to 18 hours).
Absorption
Administered intravenously, hence 100% bioavailability. Plasma concentrations decline in a triphasic manner.
Metabolism
Extensive hepatic metabolism, primarily by cytochrome P450 3A4 (CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- •Severe hypersensitivity to docetaxel or polysorbate 80
- •Baseline neutrophil count <1500 cells/mm³
- •Severe hepatic impairment
Drug Interactions
Dexamethasone
Used as premedication to reduce hypersensitivity and fluid retention, generally well-tolerated together.
CYP3A4 Inducers (e.g., phenytoin, carbamazepine, rifampin)
May decrease docetaxel plasma concentrations, potentially reducing efficacy. Avoid concomitant use or adjust docetaxel dose.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
May increase docetaxel plasma concentrations, leading to increased toxicity. Avoid concomitant use or adjust docetaxel dose with caution.
Storage
Store intact vials at 2°C to 25°C (36°F to 77°F). Protect from light. Do not freeze. Store the diluted solution at room temperature or refrigerated, depending on the manufacturer's specific guidelines.
Overdose
There is no known antidote for docetaxel overdose. The main anticipated complications of overdose include bone marrow suppression, peripheral neurotoxicity, and mucositis. Management is supportive, including appropriate measures to maintain vital signs and close monitoring of hematological parameters.
Pregnancy & Lactation
Pregnancy Category D. Docetaxel can cause fetal harm when administered to a pregnant woman. Avoid use during pregnancy. It is not known whether docetaxel is excreted in human milk; breastfeeding is contraindicated during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended. Once reconstituted/diluted, shelf-life is significantly shorter.
Availability
Hospitals, oncology clinics, specialized pharmacies
Approval Status
Approved (Generic versions widely available)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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