Deltapred
Generic Name
Prednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deltapred 10 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Deltapred 10 mg tablet contains Prednisolone, a synthetic corticosteroid. It is used to treat a wide range of inflammatory and autoimmune conditions, as well as certain cancers.
Uses & Indications
Dosage
Adults
Initial dose 5-60 mg daily, divided or as a single dose, depending on the condition and patient response. Taper dose gradually when discontinuing.
Elderly
Lower doses may be required, particularly in patients with comorbidities or those taking other medications. Close monitoring is recommended.
Renal_impairment
Generally, no dosage adjustment is required for renal impairment, but caution is advised in severe cases.
How to Take
Orally, usually once daily, preferably with food to minimize gastrointestinal upset. Should be taken as directed by a physician.
Mechanism of Action
Prednisolone works by binding to glucocorticoid receptors, leading to changes in gene expression that suppress inflammation and alter immune responses. It inhibits the release of various inflammatory mediators and reduces the activity of immune cells.
Pharmacokinetics
Onset
Varies depending on the condition, generally within hours.
Excretion
Excreted mainly in the urine, primarily as metabolites.
Half life
Biological half-life is 18-36 hours; plasma half-life is 2-4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Live or live-attenuated vaccines during immunosuppressive doses
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Insulin/Oral Hypoglycemics
May increase blood glucose, requiring dose adjustment of antidiabetic drugs.
Ketoconazole, Erythromycin
May increase prednisolone effects due to decreased metabolism.
Anticoagulants (e.g., Warfarin)
Effects may be altered, requiring dose adjustment.
Phenobarbital, Phenytoin, Rifampicin
May decrease prednisolone effects due to increased metabolism.
Diuretics (e.g., Thiazides, loop diuretics)
Increased potassium loss.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually not life-threatening. Chronic overdose can lead to severe side effects such as Cushing's syndrome, hyperglycemia, and electrolyte imbalances. Treatment is symptomatic and supportive. Gradual tapering of the dose is crucial.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Live or live-attenuated vaccines during immunosuppressive doses
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Insulin/Oral Hypoglycemics
May increase blood glucose, requiring dose adjustment of antidiabetic drugs.
Ketoconazole, Erythromycin
May increase prednisolone effects due to decreased metabolism.
Anticoagulants (e.g., Warfarin)
Effects may be altered, requiring dose adjustment.
Phenobarbital, Phenytoin, Rifampicin
May decrease prednisolone effects due to increased metabolism.
Diuretics (e.g., Thiazides, loop diuretics)
Increased potassium loss.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually not life-threatening. Chronic overdose can lead to severe side effects such as Cushing's syndrome, hyperglycemia, and electrolyte imbalances. Treatment is symptomatic and supportive. Gradual tapering of the dose is crucial.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied and is a well-established drug with numerous clinical trials supporting its efficacy and safety in various indications. Ongoing research explores new applications and optimal dosing strategies.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone density (long-term use)
- Ocular pressure (long-term use)
Doctor Notes
- Emphasize gradual tapering to avoid adrenal crisis.
- Monitor blood glucose and electrolytes, especially with co-administration of diuretics or in diabetic patients.
- Consider bone protection (calcium/vitamin D) for long-term therapy.
- Educate patients on signs of infection and importance of reporting them promptly.
Patient Guidelines
- Do not stop taking this medicine abruptly, especially after prolonged use, as it can cause serious withdrawal symptoms. Taper the dose gradually as advised by your doctor.
- Take with food to reduce stomach upset.
- Inform your doctor about all other medications and supplements you are taking.
- Report any signs of infection immediately.
- Avoid contact with people who have infections (e.g., chickenpox, measles) if you are on high doses.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Prednisolone may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you are sure you can perform such activities safely.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to manage fluid retention and blood pressure.
- Engage in regular, moderate exercise (if cleared by doctor) to maintain muscle strength and bone density.
- Avoid alcohol and smoking.
- Regularly monitor blood sugar and blood pressure if advised by your doctor.
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