Deltapred
Generic Name
deltapred-5-mg-tablet
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deltapred 5 mg tablet | ৳ 1.10 | ৳ 11.00 |
Description
Overview of the medicine
Deltapred 5 mg Tablet contains Prednisolone, a synthetic corticosteroid. It is primarily used for its potent anti-inflammatory and immunosuppressive effects. It helps to reduce inflammation and suppress the immune system in a wide range of conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition and severity, typically ranging from 5 mg to 60 mg daily. For maintenance therapy, 5-10 mg daily is common. Should be taken as a single dose in the morning or as directed by physician.
Elderly
Lower doses may be considered, particularly if there are co-morbidities or increased risk of side effects. Careful monitoring is advised.
Renal_impairment
Generally no dose adjustment required for renal impairment, but caution is advised in patients with severe renal disease due to potential fluid retention.
How to Take
Take Deltapred 5 mg Tablet orally with food or milk to minimize gastrointestinal irritation. It is often recommended to take it in the morning to align with the body's natural cortisol rhythm.
Mechanism of Action
Prednisolone works by binding to specific glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. This complex then modulates gene expression, leading to increased synthesis of anti-inflammatory proteins and decreased synthesis of pro-inflammatory proteins. It also inhibits the release of various inflammatory mediators, stabilizes lysosomal membranes, and suppresses the immune response.
Pharmacokinetics
Onset
Anti-inflammatory effects usually begin within 1-2 hours, with maximal effects observed within 4-8 hours.
Excretion
Mainly excreted in the urine as inactive metabolites, with a small proportion excreted unchanged.
Half life
Plasma half-life is approximately 2-4 hours, but the biological half-life (duration of action) is much longer, ranging from 18 to 36 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations typically occur within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites. It undergoes hepatic reduction and conjugation.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Anticoagulants (e.g., Warfarin)
Effects may be altered; requires careful monitoring of INR.
Phenobarbital, Phenytoin, Rifampicin
May decrease prednisolone efficacy by increasing its metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium loss, leading to hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal bleeding and ulceration.
Antidiabetic agents (e.g., Insulin, Oral hypoglycemics)
Prednisolone can increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to signs and symptoms of Cushing's syndrome (e.g., moon face, buffalo hump, weight gain, hypertension). Treatment is symptomatic and supportive; gradual withdrawal if long-term high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; use with caution during lactation, or consider alternative feeding methods.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Anticoagulants (e.g., Warfarin)
Effects may be altered; requires careful monitoring of INR.
Phenobarbital, Phenytoin, Rifampicin
May decrease prednisolone efficacy by increasing its metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium loss, leading to hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal bleeding and ulceration.
Antidiabetic agents (e.g., Insulin, Oral hypoglycemics)
Prednisolone can increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to signs and symptoms of Cushing's syndrome (e.g., moon face, buffalo hump, weight gain, hypertension). Treatment is symptomatic and supportive; gradual withdrawal if long-term high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; use with caution during lactation, or consider alternative feeding methods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, check specific packaging for details.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone is a well-established medicine with extensive clinical evidence supporting its efficacy and safety across various indications. Numerous clinical trials have been conducted over decades, solidifying its role in therapeutic practice.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmologic examination (for long-term use)
Doctor Notes
- Emphasize gradual tapering of dosage to prevent adrenal crisis.
- Monitor for signs of infection, hyperglycemia, and hypertension.
- Advise patients about potential mood changes and bone health management.
- Regular ophthalmologic evaluations are crucial for long-term users.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms.
- Take with food or milk to minimize stomach upset.
- Report any unusual side effects, especially signs of infection, mood changes, or severe stomach pain.
- Avoid close contact with people who are sick or have infections, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Deltapred 5 mg Tablet generally does not impair ability to drive or operate machinery. However, if you experience dizziness, blurred vision, or mood changes, avoid such activities.
Lifestyle Advice
- Maintain a low-sodium, high-potassium diet to help manage fluid retention and electrolyte balance.
- Consider calcium and vitamin D supplements to help prevent osteoporosis, especially during long-term therapy.
- Engage in regular, moderate exercise to maintain muscle strength and bone density.
- Avoid excessive alcohol consumption.
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