Dementa XR
Generic Name
Memantine HCl Extended Release
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dementa xr 7 mg capsule | ৳ 12.00 | ৳ 120.00 |
| dementa xr 14 mg capsule | ৳ 20.00 | ৳ 160.00 |
Description
Overview of the medicine
Dementa XR (Memantine HCl Extended Release) is a medication used to treat moderate to severe Alzheimer's disease. It works by affecting certain chemicals in the brain to improve memory, awareness, and the ability to function.
Uses & Indications
Dosage
Adults
Initial dose of 7 mg once daily, gradually increasing weekly in 7 mg increments to a target maintenance dose of 28 mg once daily. Doses should be taken at bedtime.
Elderly
No specific dose adjustment is needed based solely on age, but renal function should be considered.
Renal_impairment
For moderate renal impairment (CrCl 5-29 mL/min), the maximum recommended dose is 14 mg once daily. Not recommended for severe renal impairment (CrCl < 5 mL/min).
How to Take
Take orally once daily, preferably at bedtime. Capsules can be taken with or without food. Swallow the capsule whole; do not chew, crush, or divide. If unable to swallow, the capsule may be opened and the contents sprinkled onto a small amount of applesauce and consumed immediately.
Mechanism of Action
Memantine is a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors. It is thought to exert its therapeutic effect by blocking the effects of elevated tonic levels of glutamate, which is believed to contribute to the symptoms of Alzheimer's disease. Memantine binds to the NMDA receptor-operated cation channels with moderate affinity and prevents their sustained activation by glutamate.
Pharmacokinetics
Onset
Therapeutic effects may be observed within a few weeks.
Excretion
Primarily excreted unchanged in the urine, with renal clearance being highly dependent on pH.
Half life
Approximately 60-80 hours.
Absorption
Well absorbed after oral administration. Peak plasma concentrations are reached in approximately 9-12 hours for the extended-release formulation.
Metabolism
Minimally metabolized; some N-demethylation and conjugation products are formed.
Side Effects
Contraindications
- •Hypersensitivity to memantine or any component of the formulation.
Drug Interactions
Sodium Bicarbonate
May reduce memantine elimination, leading to increased plasma concentrations.
Carbonic Anhydrase Inhibitors (e.g., Acetazolamide)
May reduce memantine elimination, leading to increased plasma concentrations.
NMDA antagonists (e.g., Amantadine, Ketamine, Dextromethorphan)
Co-administration may potentiate side effects of memantine due to additive effects.
Drugs eliminated by renal tubular secretion (e.g., Cimetidine, Ranitidine, Nicotine, Quinidine)
Memantine is partially eliminated by renal tubular secretion and may interact with other drugs eliminated by this route.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, and seizures. Treatment is supportive; gastric lavage or emesis may be used. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown if memantine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent (generic versions available)
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in