Demoxiclave
Generic Name
Amoxicillin + Clavulanic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| demoxiclave 250 mg tablet | ৳ 25.00 | ৳ 175.00 |
Description
Overview of the medicine
Demoxiclave is a combination antibiotic containing amoxicillin, a penicillin-type antibiotic, and clavulanic acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections that are resistant to amoxicillin alone.
Uses & Indications
Dosage
Adults
One 250 mg tablet three times daily, or as directed by physician. For more severe infections, 500 mg three times daily.
Elderly
Dosage should be adjusted based on renal function.
Renal_impairment
Reduced dosage intervals or lower doses may be necessary depending on creatinine clearance.
How to Take
Orally, preferably at the start of a meal to minimize potential gastrointestinal intolerance.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis. Clavulanic acid inhibits beta-lactamase enzymes produced by bacteria, which would otherwise inactivate amoxicillin, thereby extending amoxicillin's spectrum of activity.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 1 hour for amoxicillin, and 1 hour for clavulanic acid.
Absorption
Well absorbed from the gastrointestinal tract; absorption is not significantly affected by food.
Metabolism
Both components are partially metabolized in the liver; amoxicillin to penicilloic acid, clavulanic acid to inactive metabolites.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics
- History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanic acid
- Severe renal impairment (without dosage adjustment)
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR.
Probenecid
Increases amoxicillin levels by decreasing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal tubular secretion.
Oral contraceptives
May reduce efficacy of oral contraceptives.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment is symptomatic and supportive. Hemodialysis can remove both components from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on storage conditions.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent (generic versions widely available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety for various bacterial infections. Ongoing post-marketing surveillance for adverse events and resistance patterns.
Lab Monitoring
- Liver function tests (especially in prolonged therapy or pre-existing hepatic impairment)
- Renal function tests (in patients with renal impairment)
- Complete blood count (in prolonged therapy)
Doctor Notes
- Confirm bacterial infection before prescribing to minimize resistance.
- Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.
- Advise patients on the importance of completing the full course.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Report any severe or persistent side effects to your doctor.
- Take with food to minimize stomach upset.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals; avoid driving or operating machinery if affected.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine
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