Deon
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deon 200000 iu injectable solution oral im | ৳ 90.00 | N/A |
Description
Overview of the medicine
Deon (Desloratadine) is a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It is a long-acting tricyclic histamine antagonist with selective H1-receptor antihistamine activity.
Uses & Indications
Dosage
Adults
Adults and adolescents (12 years and over): 5 mg once daily.
Elderly
No dosage adjustment generally required, but caution is advised in elderly patients with renal or hepatic impairment.
Renal_impairment
In patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Can be taken with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine selectively antagonizes peripheral H1-histamine receptors. It inhibits the release of histamine from mast cells and reduces the expression of adhesion molecules. It also has anti-inflammatory effects.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Excreted in urine and feces, primarily as metabolites.
Half life
Approximately 27 hours.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- •Pregnancy (unless clearly needed, Category C).
- •Lactation.
Drug Interactions
Cimetidine
May increase desloratadine plasma levels.
Fluoxetine
May increase desloratadine plasma levels.
Azithromycin
May increase desloratadine plasma levels.
Erythromycin
May increase desloratadine plasma levels.
Ketoconazole
May increase desloratadine plasma levels.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment should be initiated. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk, so use is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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