Depo-Pred
Generic Name
Methylprednisolone Acetate
Manufacturer
Various manufacturers (e.g., Pfizer, Eskayef)
Country
Global
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Description
Overview of the medicine
Depo-Pred is a long-acting corticosteroid injection used to treat various inflammatory and autoimmune conditions, including rheumatic disorders, allergic states, dermatological diseases, and certain respiratory conditions. It works by decreasing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically, 40-120 mg intramuscularly, repeated as needed, usually every 1-4 weeks. Intra-articular doses range from 4 mg to 80 mg.
Elderly
No specific dose adjustments needed solely based on age, but caution is advised due to potential comorbidities and increased risk of side effects (e.g., osteoporosis).
Renal_impairment
No routine dosage adjustment is typically required, as methylprednisolone is primarily metabolized by the liver.
How to Take
Administer deep into a large muscle mass (e.g., gluteal muscle). For intra-articular or intralesional use, follow specific medical guidelines. DO NOT administer intravenously.
Mechanism of Action
Methylprednisolone Acetate acts by binding to specific intracellular glucocorticoid receptors, forming a steroid-receptor complex that translocates into the nucleus. This complex then modulates gene expression, leading to the synthesis of anti-inflammatory proteins (e.g., lipocortins) and inhibition of pro-inflammatory mediators (e.g., prostaglandins, leukotrienes, cytokines). It also suppresses immune cell function.
Pharmacokinetics
Onset
Onset of action typically ranges from hours to days, with full therapeutic effects developing over several days due to the depot nature.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2.5-3.5 hours, but the biological half-life (duration of action) is much longer, ranging from 18 to 36 hours due to its sustained release from the depot formulation.
Absorption
Slowly absorbed from the site of intramuscular injection, providing a sustained therapeutic effect. Peak plasma levels are reached 4-8 hours post-injection.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- •Systemic fungal infections
- •Known hypersensitivity to methylprednisolone or any component of the formulation
- •Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (e.g., Warfarin)
Effects may be altered; close monitoring of INR is needed.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration.
CYP3A4 Inducers (e.g., Phenobarbital, Rifampin)
May decrease corticosteroid levels, requiring dose increase.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase corticosteroid levels, requiring dose reduction.
Storage
Store at controlled room temperature (20°C to 25°C), protect from light and freezing.
Overdose
Acute overdose is rare. Chronic overdose can lead to Cushingoid features, fluid retention, hypertension, hyperglycemia, and psychiatric symptoms. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to package insert for specific expiry date
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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