Derma-Aid
Generic Name
Hydrocortisone 0.5% w/w Ointment
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| derma aid 5 mg ointment | ৳ 24.00 | N/A |
Description
Overview of the medicine
Hydrocortisone 0.5% w/w Ointment is a mild topical corticosteroid used to reduce inflammation, redness, itching, and discomfort associated with various mild to moderate inflammatory skin conditions such as eczema, dermatitis, and psoriasis.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area 2-3 times daily, or as directed by a physician. Gently rub in. Do not use for more than 1-2 weeks without medical advice.
Elderly
No specific dose adjustment is typically required, but use with caution due to thinner skin and potential for increased absorption. Monitor for side effects.
Renal_impairment
No specific dose adjustment needed for topical application, as systemic absorption is minimal.
How to Take
For external use only. Apply a thin film to the affected skin area and gently massage it in. Wash hands thoroughly before and after application. Avoid contact with eyes, mouth, and other mucous membranes. Do not use under occlusive dressings unless specifically advised by a doctor.
Mechanism of Action
Hydrocortisone acts by diffusing across cell membranes and binding to specific cytoplasmic glucocorticoid receptors. These complexes then enter the nucleus, bind to DNA, and modulate gene expression, leading to anti-inflammatory, immunosuppressive, and vasoconstrictive effects at the site of application.
Pharmacokinetics
Onset
Symptom relief typically observed within hours to a few days of consistent application.
Excretion
Excreted mainly by the kidneys as inactive metabolites and some unmetabolized drug.
Half life
Systemic plasma half-life of absorbed hydrocortisone is approximately 1.5-2 hours. Local tissue half-life is longer.
Absorption
Variable systemic absorption through the skin; enhanced by inflammation, skin barrier disruption, occlusive dressings, and application to large surface areas.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to hydrocortisone or any other ingredient of the ointment.
- Untreated bacterial, fungal, viral (e.g., herpes simplex, varicella), or parasitic skin infections.
- Acne vulgaris, rosacea, perioral dermatitis.
- Pruritus without inflammation.
- Ulcerated skin lesions, tuberculosis of the skin, vaccinia.
Drug Interactions
No significant systemic interactions
Due to minimal systemic absorption, clinically significant drug interactions are unlikely with typical topical use.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Do not freeze. Keep out of the sight and reach of children.
Overdose
Acute overdose is unlikely with topical hydrocortisone. Chronic overdose or misuse, especially over large areas or under occlusion, can lead to local adverse effects (e.g., skin atrophy) and systemic effects (e.g., Cushing's syndrome, adrenal suppression). Management involves gradual withdrawal of the steroid under medical supervision.
Pregnancy & Lactation
Use during pregnancy and lactation should be undertaken with caution and only if the potential benefit justifies the potential risk to the fetus or infant. Avoid prolonged use, large surface area application, or application under occlusion. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to hydrocortisone or any other ingredient of the ointment.
- Untreated bacterial, fungal, viral (e.g., herpes simplex, varicella), or parasitic skin infections.
- Acne vulgaris, rosacea, perioral dermatitis.
- Pruritus without inflammation.
- Ulcerated skin lesions, tuberculosis of the skin, vaccinia.
Drug Interactions
No significant systemic interactions
Due to minimal systemic absorption, clinically significant drug interactions are unlikely with typical topical use.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Do not freeze. Keep out of the sight and reach of children.
Overdose
Acute overdose is unlikely with topical hydrocortisone. Chronic overdose or misuse, especially over large areas or under occlusion, can lead to local adverse effects (e.g., skin atrophy) and systemic effects (e.g., Cushing's syndrome, adrenal suppression). Management involves gradual withdrawal of the steroid under medical supervision.
Pregnancy & Lactation
Use during pregnancy and lactation should be undertaken with caution and only if the potential benefit justifies the potential risk to the fetus or infant. Avoid prolonged use, large surface area application, or application under occlusion. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Generic/Off-patent
WHO Essential Medicine
YesClinical Trials
Hydrocortisone, as a well-established corticosteroid, has extensive clinical data supporting its efficacy and safety for various inflammatory dermatoses. Specific trials for this generic formulation would typically demonstrate bioequivalence.
Lab Monitoring
- Routine laboratory monitoring is generally not required for typical topical use of hydrocortisone 0.5% w/w. In cases of extensive or prolonged use, especially in children, monitoring for adrenal suppression may be considered.
Doctor Notes
- Emphasize appropriate application technique and duration to minimize local and systemic side effects.
- Counsel patients on the importance of avoiding use on the face, groin, or axillae unless specifically indicated and supervised.
- Educate on signs of local skin adverse effects and when to discontinue treatment and seek medical advice.
Patient Guidelines
- Apply a very thin layer only to the affected skin areas.
- Do not cover the treated area with bandages or other dressings unless directed by a doctor.
- Avoid using this ointment on the face, groin, or underarms unless specifically instructed by your doctor.
- Do not use for longer than the prescribed duration, typically 1-2 weeks.
- Keep out of reach of children and pets.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Derma-Aid 5 mg Ointment is for topical use only and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene and moisturize regularly to support skin barrier function.
- Avoid known irritants or allergens that may trigger or worsen your skin condition.
- Wear loose, breathable clothing to minimize irritation to affected areas.
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