Dermastin
Generic Name
Clobetasol Propionate
Manufacturer
ACI Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dermastin 05 mg cream | ৳ 60.00 | N/A |
Description
Overview of the medicine
Dermastin 0.05% w/w Cream contains Clobetasol Propionate, a highly potent corticosteroid, used for short-term treatment of inflammatory skin conditions unresponsive to less potent corticosteroids.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily for a maximum of two weeks. Do not use more than 50g per week.
Elderly
Use with caution and for the shortest possible duration, as skin thinning may be more pronounced.
Renal_impairment
No specific dosage adjustment required, but systemic absorption should be monitored if large areas are treated.
How to Take
For topical dermatological use only. Apply a small amount of cream to the affected skin and rub gently until it disappears. Wash hands after application unless hands are the treated area.
Mechanism of Action
Clobetasol Propionate is a topical corticosteroid that acts by inducing phospholipase A2 inhibitory proteins, lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Onset
Within hours of application.
Excretion
Excreted mainly via the kidneys, with some excretion in bile.
Half life
Not well established for topical application; systemic half-life of absorbed clobetasol is about 3-5 hours.
Absorption
Minimal systemic absorption occurs through intact skin; absorption increases with skin damage, occlusion, or application to large surface areas.
Metabolism
Metabolized primarily in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or any components of the cream
- Rosacea, perioral dermatitis, acne vulgaris
- Pruritus without inflammation
- Perianal and genital pruritus
- Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
- Primary bacterial or fungal skin infections
- Children under 1 year of age
Drug Interactions
CYP3A4 Inhibitors (e.g., Ritonavir, Itraconazole)
Co-administration with potent CYP3A4 inhibitors may increase systemic exposure to clobetasol, leading to an increased risk of systemic side effects. Use with caution.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to systemic effects such as Cushing's syndrome, hyperglycemia, and HPA axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus, and under strict medical supervision. Avoid use on large areas or for prolonged periods. Consult a doctor before use during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or any components of the cream
- Rosacea, perioral dermatitis, acne vulgaris
- Pruritus without inflammation
- Perianal and genital pruritus
- Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
- Primary bacterial or fungal skin infections
- Children under 1 year of age
Drug Interactions
CYP3A4 Inhibitors (e.g., Ritonavir, Itraconazole)
Co-administration with potent CYP3A4 inhibitors may increase systemic exposure to clobetasol, leading to an increased risk of systemic side effects. Use with caution.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to systemic effects such as Cushing's syndrome, hyperglycemia, and HPA axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus, and under strict medical supervision. Avoid use on large areas or for prolonged periods. Consult a doctor before use during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Patent expired for generic Clobetasol Propionate
Clinical Trials
Extensive clinical trials support the efficacy and safety of Clobetasol Propionate for its approved indications.
Lab Monitoring
- If used on large body areas or for prolonged periods, monitor for signs of HPA axis suppression (e.g., morning plasma cortisol levels).
- Blood glucose monitoring in diabetic patients.
Doctor Notes
- Prescribe for short-term use only (max 2 weeks, or 1 week on face).
- Advise patients on proper application technique and avoiding occlusive dressings.
- Caution against use in children, on face, groin, and axillae due to increased systemic absorption and skin atrophy risk.
- Monitor for signs of HPA axis suppression if used extensively or for prolonged periods.
Patient Guidelines
- Use exactly as prescribed by your doctor; do not exceed the recommended duration (usually 2 weeks).
- Do not apply to the face, groin, or armpits unless specifically directed by a doctor.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use under occlusive dressings or diapers unless advised by a doctor.
- Inform your doctor if your condition worsens or does not improve after 2 weeks of treatment.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
Driving Precautions
Dermastin 0.05% w/w Cream has no known influence on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene to prevent secondary infections.
- Avoid irritants that may worsen your skin condition.
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