Desatrol
Generic Name
Desloratadine
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desatrol 5 mg tablet | ৳ 2.51 | ৳ 25.10 |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, watery eyes, and itching. It also helps alleviate symptoms of chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
5 mg once daily, with or without food.
Elderly
No dosage adjustment necessary, but use with caution in patients with renal or hepatic impairment.
Renal_impairment
For patients with renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Take orally, with or without food, at approximately the same time each day. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby reducing the allergic response. It also inhibits the release of pro-inflammatory mediators from mast cells and basophils.
Pharmacokinetics
Onset
Onset of action within 30 minutes for symptomatic relief.
Excretion
Excreted almost equally in the urine and feces as metabolites.
Half life
Mean elimination half-life is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached approximately 3 hours after dosing.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily via hydroxylation and subsequent conjugation.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe kidney disease should use with caution.
Drug Interactions
Cimetidine
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Fluoxetine
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Azithromycin
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Erythromycin
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Ketoconazole
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Desloratadine is not effectively removed by hemodialysis. Consult a healthcare professional immediately.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe kidney disease should use with caution.
Drug Interactions
Cimetidine
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Fluoxetine
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Azithromycin
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Erythromycin
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Ketoconazole
May increase plasma concentrations of desloratadine, but without clinically significant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Desloratadine is not effectively removed by hemodialysis. Consult a healthcare professional immediately.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
Clinical Trials
Extensive clinical trials have demonstrated desloratadine's efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific routine lab monitoring is required for desloratadine.
Doctor Notes
- Consider renal function in elderly patients or those with pre-existing renal impairment, and adjust dosage accordingly.
- Counsel patients on the non-sedating nature of the drug but advise caution until individual response is known.
- Review patient's complete medication list to identify potential drug interactions, although significant interactions are rare.
Patient Guidelines
- Take Desatrol exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Inform your doctor if your symptoms do not improve or worsen.
- Avoid alcohol while taking this medication, although no significant interaction has been reported.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Although desloratadine is generally non-sedating, individuals may react differently. Exercise caution when driving or operating machinery until you know how Desatrol affects you.
Lifestyle Advice
- Identify and avoid known allergens where possible.
- Maintain good hydration.
- Ensure adequate rest.
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Global Brand Names
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