Deslosil
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deslosil 5 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Deslosil (Desloratadine) is a non-sedating antihistamine used to relieve symptoms of allergic rhinitis (e.g., sneezing, runny nose, itchy eyes) and chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
5 mg once daily.
Elderly
No dosage adjustment is generally required, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Deslosil tablets should be taken orally, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine is a potent, long-acting, selective peripheral H1-receptor antagonist. It inhibits the release of histamine from mast cells and basophils and also blocks various inflammatory mediators like leukotrienes and prostaglandins.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 27 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached approximately 3 hours after dosing.
Metabolism
Extensively metabolized in the liver to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Children under 12 years (for tablets).
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine.
Fluoxetine
Increased plasma concentrations of desloratadine.
Erythromycin
Increased plasma concentrations of desloratadine.
Ketoconazole
Increased plasma concentrations of desloratadine.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Children under 12 years (for tablets).
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine.
Fluoxetine
Increased plasma concentrations of desloratadine.
Erythromycin
Increased plasma concentrations of desloratadine.
Ketoconazole
Increased plasma concentrations of desloratadine.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, consult product packaging for exact date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety for treating allergic rhinitis and chronic idiopathic urticaria across various age groups.
Lab Monitoring
- Routine laboratory monitoring is generally not required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms of hepatic dysfunction occur.
Doctor Notes
- Educate patients on the non-sedating nature, but advise caution with initial use.
- Remind patients about the importance of consistent daily dosing for optimal effect.
- Counsel on avoiding triggers and adjunctive measures for allergy relief.
Patient Guidelines
- Take Deslosil exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if your symptoms do not improve or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Deslosil is generally considered non-sedating. However, individual responses vary. Patients should be advised to exercise caution when engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Avoid known allergens that trigger your symptoms.
- Maintain good hydration.
- Consider using saline nasal rinses for allergic rhinitis symptoms.
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Global Brand Names
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