Desotem
Generic Name
Desotem
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desotem 25 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Desotem 25 mg Syrup is a non-sedating antihistamine used to relieve symptoms of allergic rhinitis (seasonal and perennial) and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
Adults and adolescents (12 years and older): 50 mg (10 mL) once daily.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution is advised due to potential age-related decrease in renal function.
Renal_impairment
For patients with moderate to severe renal impairment (creatinine clearance <50 mL/min), the recommended dose is 25 mg (5 mL) every other day.
How to Take
Administer orally, with or without food. Use the provided measuring device (e.g., syringe or cup) to ensure accurate dosing, especially for children. Shake well before use.
Mechanism of Action
Desotem selectively antagonizes peripheral H1-receptors, thereby inhibiting the effects of histamine and reducing allergic symptoms such as sneezing, runny nose, itching, and hives.
Pharmacokinetics
Onset
Symptom relief usually begins within 30 minutes to 1 hour.
Excretion
Approximately 70% of the dose is excreted via urine and 20% via feces, mainly as metabolites.
Half life
The elimination half-life is approximately 15-20 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations typically achieved within 1 to 2 hours.
Metabolism
Primarily metabolized in the liver through hydroxylation, followed by conjugation, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Desotem, desloratadine, loratadine, or any component of the formulation.
- Severe hepatic impairment, as safety and efficacy have not been fully established.
Drug Interactions
Cimetidine
May slightly increase Desotem plasma levels, but not clinically significant in most cases.
Erythromycin
Concomitant administration with erythromycin may lead to increased plasma concentrations of Desotem. Monitor for increased adverse effects.
Ketoconazole
Concomitant administration with ketoconazole may lead to increased plasma concentrations of Desotem. Monitor for increased adverse effects.
Storage
Store below 30°C in a dry place, protected from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, headache, and palpitations. Management is symptomatic and supportive. Consider gastric lavage and administration of activated charcoal if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Desotem is likely excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Desotem, desloratadine, loratadine, or any component of the formulation.
- Severe hepatic impairment, as safety and efficacy have not been fully established.
Drug Interactions
Cimetidine
May slightly increase Desotem plasma levels, but not clinically significant in most cases.
Erythromycin
Concomitant administration with erythromycin may lead to increased plasma concentrations of Desotem. Monitor for increased adverse effects.
Ketoconazole
Concomitant administration with ketoconazole may lead to increased plasma concentrations of Desotem. Monitor for increased adverse effects.
Storage
Store below 30°C in a dry place, protected from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, headache, and palpitations. Management is symptomatic and supportive. Consider gastric lavage and administration of activated charcoal if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Desotem is likely excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture. Once opened, use within 28 days.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Desotem underwent extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and urticaria. Ongoing post-marketing surveillance continues to gather real-world data.
Lab Monitoring
- No specific routine laboratory monitoring is required for Desotem.
- In patients with known renal or hepatic impairment, monitoring of kidney and liver function tests may be advisable.
Doctor Notes
- Ensure patients understand the correct dosing for their age/weight using the provided measuring device to avoid under- or over-dosing.
- Advise patients that while Desotem is typically non-sedating, individual reactions can occur, so caution with activities requiring mental alertness is important.
- Counsel patients on potential drug interactions, especially with strong CYP3A4 inhibitors.
Patient Guidelines
- Always use the provided measuring device for accurate dosing; do not use household spoons.
- Do not exceed the recommended dose as this may increase the risk of side effects.
- Inform your doctor or pharmacist about all other medications, herbal supplements, and vitamins you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Desotem is generally non-sedating. However, individual responses may vary. Patients should be advised to observe their response to the drug and exercise caution when driving or operating machinery until they are sure the drug does not affect them adversely.
Lifestyle Advice
- Identify and avoid triggers for your allergies, such as pollen, dust mites, or certain foods.
- Maintain good indoor air quality and cleanliness to reduce exposure to allergens.
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