Dexogut
Generic Name
Dexlansoprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexogut 30 mg capsule | ৳ 11.50 | ৳ 115.00 |
Description
Overview of the medicine
Dexogut 30 mg Capsule contains Dexlansoprazole, a proton pump inhibitor (PPI) used to decrease the amount of acid produced in the stomach. It is prescribed for the healing of erosive esophagitis (acid-related damage to the esophagus) and for the symptomatic treatment of non-erosive gastroesophageal reflux disease (GERD).
Uses & Indications
Dosage
Adults
Healing of EE: 60 mg once daily for up to 8 weeks. Maintenance of EE: 30 mg once daily. Symptomatic non-erosive GERD: 30 mg once daily for up to 4 weeks.
Elderly
No dosage adjustment necessary based on age alone. However, caution should be exercised in very elderly patients due to potential comorbidities.
Renal_impairment
No dosage adjustment is needed for patients with mild to moderate renal impairment. For severe renal impairment, use with caution due to limited data.
How to Take
Take Dexogut capsule orally, with or without food. Swallow the capsule whole; do not chew, crush, or open the capsule.
Mechanism of Action
Dexlansoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells. This action specifically blocks the final step in acid production.
Pharmacokinetics
Onset
Acid suppression begins within a few hours of administration.
Excretion
Approximately 60% of the dose is excreted in urine and 23% in feces as inactive metabolites.
Half life
Approximately 1-2 hours (terminal elimination half-life).
Absorption
Absorbed after oral administration, exhibiting a dual delayed-release profile. The first release occurs within 1 hour, and the second release occurs 4-5 hours later. Bioavailability is about 76%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 (CYP) isoenzymes CYP2C19 and CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any other component of the formulation
- Known hypersensitivity to other proton pump inhibitors
Drug Interactions
Digoxin
Increased systemic exposure to digoxin has been reported; monitor digoxin levels.
Warfarin
Increased INR and prothrombin time have been reported with concomitant PPI use, requiring monitoring.
Clopidogrel
Potential for reduced antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.
Methotrexate
Possible increased and prolonged elevation of serum methotrexate levels and/or its metabolite, particularly with high doses.
Atazanavir, Nelfinavir
Dexlansoprazole may reduce the absorption of these antiretrovirals, leading to decreased efficacy. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with dexlansoprazole overdose is limited. Reported symptoms include mild to moderate gastrointestinal disturbances. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether dexlansoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any other component of the formulation
- Known hypersensitivity to other proton pump inhibitors
Drug Interactions
Digoxin
Increased systemic exposure to digoxin has been reported; monitor digoxin levels.
Warfarin
Increased INR and prothrombin time have been reported with concomitant PPI use, requiring monitoring.
Clopidogrel
Potential for reduced antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.
Methotrexate
Possible increased and prolonged elevation of serum methotrexate levels and/or its metabolite, particularly with high doses.
Atazanavir, Nelfinavir
Dexlansoprazole may reduce the absorption of these antiretrovirals, leading to decreased efficacy. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with dexlansoprazole overdose is limited. Reported symptoms include mild to moderate gastrointestinal disturbances. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether dexlansoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
FDA approved (for generic molecule)
Patent Status
Patent expired (for generic dexlansoprazole)
Clinical Trials
Dexlansoprazole has undergone extensive clinical trials demonstrating its efficacy and safety for the approved indications. Studies have shown its superiority or non-inferiority compared to other PPIs in certain conditions.
Lab Monitoring
- Monitor serum magnesium levels periodically in patients expected to be on prolonged treatment or who take dexlansoprazole with other drugs that may cause hypomagnesemia.
- Monitor INR/PT in patients concomitantly treated with warfarin.
Doctor Notes
- Ensure proper diagnosis of GERD or EE before initiating PPI therapy.
- Consider the lowest effective dose for the shortest duration necessary.
- Advise patients on lifestyle modifications to complement drug therapy.
- Be aware of potential drug interactions, especially with warfarin, clopidogrel, and atazanavir.
Patient Guidelines
- Take the capsule whole; do not chew or crush it.
- Follow your doctor's instructions regarding the dosage and duration of treatment.
- Do not stop taking the medication abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Dexlansoprazole is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or blurred vision, avoid these activities.
Lifestyle Advice
- Avoid trigger foods and drinks that worsen GERD symptoms (e.g., fatty foods, spicy foods, caffeine, alcohol, acidic juices).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed to help reduce nighttime reflux.
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