Dexogut
Generic Name
Dexlansoprazole
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexogut 60 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Dexogut 60 mg Capsule is a proton pump inhibitor used to treat various gastrointestinal conditions caused by excessive stomach acid.
Uses & Indications
Dosage
Adults
For healing of EE: 60 mg once daily for up to 8 weeks. For maintenance of healed EE and relief of heartburn: 30 mg or 60 mg once daily. For symptomatic non-erosive GERD: 30 mg once daily for 4 weeks.
Elderly
No dosage adjustment necessary for elderly patients.
Renal_impairment
No dosage adjustment necessary for patients with renal impairment.
How to Take
May be taken with or without food. Swallow the capsule whole; do not chew or crush. For patients who have difficulty swallowing, capsules may be opened and sprinkled onto a tablespoon of applesauce and swallowed immediately.
Mechanism of Action
Dexlansoprazole is a proton pump inhibitor that blocks the final step in gastric acid secretion by irreversibly binding to the H+/K+-ATPase enzyme system at the secretory surface of the gastric parietal cells.
Pharmacokinetics
Onset
Within 2-3 hours for acid suppression.
Excretion
Mainly excreted in urine (about 50%) and feces (about 23%) as metabolites.
Half life
Approximately 1-2 hours.
Absorption
Well absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Digoxin
Increased absorption of digoxin, monitor digoxin levels.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Tacrolimus
Increased tacrolimus levels, monitor closely.
Clopidogrel
Potential reduction in clopidogrel's antiplatelet effect, consider alternative PPIs or antiplatelet therapy.
Methotrexate
Increased and prolonged methotrexate serum levels, monitor for toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended in case of overdose.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. It is unknown if dexlansoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Digoxin
Increased absorption of digoxin, monitor digoxin levels.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Tacrolimus
Increased tacrolimus levels, monitor closely.
Clopidogrel
Potential reduction in clopidogrel's antiplatelet effect, consider alternative PPIs or antiplatelet therapy.
Methotrexate
Increased and prolonged methotrexate serum levels, monitor for toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended in case of overdose.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. It is unknown if dexlansoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, check package for specific expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent protected (brand specific), Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in healing and maintenance of erosive esophagitis and in symptomatic GERD.
Lab Monitoring
- Monitor magnesium levels (especially with prolonged use or with other drugs that cause hypomagnesemia)
- Monitor for Vitamin B12 deficiency with prolonged use (more than 3 years)
Doctor Notes
- Consider lowest effective dose and shortest duration of therapy to minimize risks.
- Evaluate potential drug interactions, especially with warfarin, clopidogrel, and methotrexate.
- Advise patients on lifestyle modifications to manage GERD symptoms.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not crush, chew, or open the capsule unless specifically instructed by your doctor for administration with applesauce.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness; caution should be exercised when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn, such as fatty or spicy foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Avoid lying down for at least 3 hours after eating.
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Global Brand Names
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