Dezacot
Generic Name
Deflazacort 24 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dezacot 24 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Dezacot 24 mg tablet contains Deflazacort, which is a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Initial dosage varies depending on the condition. For most conditions, 6-90 mg orally once daily, adjusted based on patient response. The lowest effective dose should be used for the shortest duration possible.
Elderly
No specific dose adjustment is generally required, but close monitoring for adverse effects is recommended due to potential increased sensitivity.
Renal_impairment
No specific dose adjustment is usually necessary for patients with renal impairment, but caution is advised. Regular monitoring may be beneficial.
How to Take
Take Dezacot 24 mg tablet orally with or without food, usually once daily in the morning to align with the body's natural cortisol rhythm. Do not crush or chew the tablet.
Mechanism of Action
Deflazacort is a glucocorticoid with anti-inflammatory and immunosuppressive properties. It acts by binding to glucocorticoid receptors, thereby altering gene expression to produce its therapeutic effects, including inhibition of prostaglandin synthesis and release of pro-inflammatory cytokines.
Pharmacokinetics
Onset
Clinical effects may be observed within a few hours to days, depending on the condition being treated.
Excretion
Mainly excreted in urine (about 70%) and feces (about 30%) as metabolites, with only a small fraction of unchanged drug.
Half life
The active metabolite (21-desacetyl deflazacort) has a plasma half-life of 1.5-2 hours.
Absorption
Well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1.5 to 2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, to its active metabolite 21-desacetyl deflazacort, which is responsible for most of its pharmacological activity.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Antidiabetic agents
May reduce the hypoglycemic effect; dose adjustment of antidiabetics may be required.
Anticoagulants (e.g., Warfarin)
Effects may be altered; monitor INR closely.
Diuretics (e.g., Thiazides, Loop Diuretics)
Increased risk of hypokalemia.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease Deflazacort levels, reducing efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Deflazacort levels, increasing risk of side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects such as fluid retention, increased blood pressure, hyperglycemia, and adrenal suppression. Treatment is supportive and symptomatic; gradual withdrawal if long-term high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk; therefore, caution should be exercised when Dezacot is administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Antidiabetic agents
May reduce the hypoglycemic effect; dose adjustment of antidiabetics may be required.
Anticoagulants (e.g., Warfarin)
Effects may be altered; monitor INR closely.
Diuretics (e.g., Thiazides, Loop Diuretics)
Increased risk of hypokalemia.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease Deflazacort levels, reducing efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Deflazacort levels, increasing risk of side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects such as fluid retention, increased blood pressure, hyperglycemia, and adrenal suppression. Treatment is supportive and symptomatic; gradual withdrawal if long-term high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk; therefore, caution should be exercised when Dezacot is administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, check expiry date on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities in many countries including Bangladesh.
Patent Status
Off-patent
Clinical Trials
Deflazacort has undergone numerous clinical trials demonstrating its efficacy and safety across various inflammatory and autoimmune conditions, including Duchenne muscular dystrophy. Research continues for new indications and long-term safety profiles.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolyte levels (e.g., potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmic examinations (for long-term use)
Doctor Notes
- Educate patients on the importance of gradual dose tapering to prevent adrenal crisis.
- Monitor blood glucose, electrolytes, and blood pressure regularly, especially for long-term users.
- Consider bone protective measures (calcium, vitamin D, bisphosphonates) for patients on prolonged therapy.
- Advise patients to report any signs of infection promptly due to immunosuppressive effects.
Patient Guidelines
- Do not stop taking this medicine abruptly, especially after long-term use, as it may lead to adrenal crisis. Your doctor will gradually reduce the dose.
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual or severe side effects to your doctor immediately.
- Avoid close contact with people who have infections like chickenpox or measles, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Dezacot may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet, possibly with reduced salt intake to manage fluid retention.
- Ensure adequate calcium and vitamin D intake to minimize bone loss risk.
- Engage in regular, moderate exercise, if suitable, to maintain muscle strength.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Dezacot Brand
Other medicines available under the same brand name
