Dipan
Generic Name
dipan-05-mg-tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dipan 05 mg tablet | ৳ 6.60 | ৳ 66.00 |
Description
Overview of the medicine
Dipan 05 mg Tablet contains Diazepam, a benzodiazepine, used to treat anxiety, insomnia, seizures, and muscle spasms.
Uses & Indications
Dosage
Adults
Anxiety: 2-10 mg, 2-4 times daily. Insomnia: 5-15 mg at bedtime. Muscle spasm: 2-10 mg, 3-4 times daily.
Elderly
Lower doses, e.g., 2-2.5 mg, 1-2 times daily, to be increased cautiously.
Renal_impairment
No specific dose adjustment recommended, but use with caution.
How to Take
Oral, with or without food.
Mechanism of Action
Diazepam enhances the effect of gamma-aminobutyric acid (GABA) at the GABAA receptor, leading to sedative, anxiolytic, anticonvulsant, and muscle relaxant properties.
Pharmacokinetics
Onset
30-60 minutes (oral)
Excretion
Mainly renal, as conjugated metabolites.
Half life
20-100 hours (due to active metabolites)
Absorption
Well absorbed from the gastrointestinal tract, peak plasma concentrations reached within 1-1.5 hours.
Metabolism
Primarily hepatic, via CYP3A4 and CYP2C19, producing active metabolites like desmethyldiazepam, temazepam, and oxazepam.
Side Effects
Contraindications
- Hypersensitivity to diazepam or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
Drug Interactions
Opioids
Increased risk of sedation, respiratory depression, coma, and death.
Phenytoin
May alter phenytoin levels.
Alcohol/CNS depressants
Potentiates sedative effects.
Cimetidine, Omeprazole, Fluoxetine
May inhibit diazepam metabolism, increasing its plasma levels.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, coma. Treatment is supportive; flumazenil may be used as an antidote.
Pregnancy & Lactation
Pregnancy Category D. Avoid during pregnancy, especially first trimester. Excreted in breast milk, avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to diazepam or other benzodiazepines
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
Drug Interactions
Opioids
Increased risk of sedation, respiratory depression, coma, and death.
Phenytoin
May alter phenytoin levels.
Alcohol/CNS depressants
Potentiates sedative effects.
Cimetidine, Omeprazole, Fluoxetine
May inhibit diazepam metabolism, increasing its plasma levels.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, coma. Treatment is supportive; flumazenil may be used as an antidote.
Pregnancy & Lactation
Pregnancy Category D. Avoid during pregnancy, especially first trimester. Excreted in breast milk, avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied since its introduction, with numerous clinical trials establishing its efficacy and safety profile for various indications.
Lab Monitoring
- Liver function tests (with long-term use)
Doctor Notes
- Caution in patients with respiratory insufficiency, hepatic or renal impairment.
- Monitor for signs of dependence and withdrawal.
- Counsel patients on potential for drowsiness and impaired coordination.
Patient Guidelines
- Do not stop taking abruptly to avoid withdrawal symptoms.
- Avoid alcohol while on this medication.
- Inform your doctor about all other medications you are taking.
- May impair ability to drive or operate machinery.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for your next dose. Do not double doses.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Practice relaxation techniques.
- Maintain a regular sleep schedule.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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