Disartan
Generic Name
Valsartan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| disartan 5 mg tablet | ৳ 16.00 | ৳ 224.00 |
Description
Overview of the medicine
Disartan (Valsartan) is an angiotensin II receptor blocker (ARB) used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of a natural substance that tightens blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently.
Uses & Indications
Dosage
Adults
For hypertension: Initial dose 80 mg or 160 mg once daily. Max 320 mg/day. For heart failure: Initial dose 40 mg twice daily. Gradually titrate up to 160 mg twice daily as tolerated. Post-MI: Initial dose 20 mg twice daily, increasing to 160 mg twice daily.
Elderly
No dose adjustment is required in elderly patients, but starting with a lower dose may be considered.
Renal_impairment
No initial dose adjustment is required for patients with mild to moderate renal impairment. For severe renal impairment or dialysis, caution is advised and dose adjustment may be necessary based on clinical response.
How to Take
Disartan can be taken with or without food. It should be taken orally with water, usually once or twice daily as directed by your doctor.
Mechanism of Action
Valsartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is responsible for the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This leads to vasodilation, reduced peripheral resistance, and decreased blood pressure.
Pharmacokinetics
Onset
Onset of antihypertensive effect within approximately 2 hours; maximum reduction in blood pressure typically achieved within 4-6 weeks.
Excretion
Excreted primarily in feces (about 83% of the dose) and urine (about 13% of the dose) as unchanged drug and metabolites.
Half life
Approximately 6-9 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring 2-4 hours post-dose. Absolute bioavailability averages about 23%. Food decreases the extent of absorption by about 40%.
Metabolism
Minimally metabolized; only about 20% of the dose is metabolized, primarily by direct glucuronidation. CYP450 enzymes are not involved.
Side Effects
Contraindications
- Hypersensitivity to valsartan or any component of the formulation
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
Drug Interactions
Lithium
Concurrent use with valsartan may increase serum lithium concentrations and toxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of valsartan and increase the risk of renal impairment, especially in elderly or dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension with dizziness and syncope. Treatment should be symptomatic and supportive, including maintaining cardiovascular stability with intravenous fluids. Valsartan is not removable by hemodialysis.
Pregnancy & Lactation
Valsartan is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal injury and death. It is not recommended during the first trimester. It is unknown whether valsartan is excreted in human milk, but due to the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to valsartan or any component of the formulation
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
Drug Interactions
Lithium
Concurrent use with valsartan may increase serum lithium concentrations and toxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of valsartan and increase the risk of renal impairment, especially in elderly or dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension with dizziness and syncope. Treatment should be symptomatic and supportive, including maintaining cardiovascular stability with intravenous fluids. Valsartan is not removable by hemodialysis.
Pregnancy & Lactation
Valsartan is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal injury and death. It is not recommended during the first trimester. It is unknown whether valsartan is excreted in human milk, but due to the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
Clinical Trials
Valsartan has undergone extensive clinical trials, including the CHARM program for heart failure and the VALUE trial for hypertension, demonstrating its efficacy and safety in various cardiovascular conditions.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or those taking potassium-sparing diuretics)
- Renal function (BUN and serum creatinine)
Doctor Notes
- Educate patients on the importance of adherence, especially in chronic conditions like hypertension and heart failure.
- Advise patients to report any symptoms of angioedema (swelling of face, lips, tongue, or throat) immediately.
- Monitor serum potassium and renal function periodically, particularly when initiating therapy or increasing dosage.
Patient Guidelines
- Take Disartan regularly as prescribed, even if you feel well.
- Do not stop taking the medicine without consulting your doctor.
- Monitor your blood pressure regularly at home if advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
Disartan may cause dizziness or fatigue. Patients should be cautioned about operating machinery or driving until they know how Disartan affects them.
Lifestyle Advice
- Adopt a low-sodium diet and limit alcohol intake.
- Engage in regular physical activity.
- Maintain a healthy weight and quit smoking.
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