Disogen
Generic Name
Disogen
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| disogen 2 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Disogen 2 mg Tablet is a potassium-sparing diuretic used to treat conditions such as edema, hypertension, and heart failure by helping the body excrete excess salt and water while retaining potassium.
Uses & Indications
Dosage
Adults
Initial dose 2 mg daily. May be increased to 4 mg daily if needed, based on clinical response and serum potassium levels. Take with food to enhance absorption.
Elderly
Start with 2 mg daily. Monitor electrolyte levels closely. Dose adjustment may be needed due to altered renal function.
Renal_impairment
Contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Use with extreme caution and reduced frequency in mild to moderate impairment, with strict electrolyte monitoring.
How to Take
Oral administration. Take the tablet with or without food, preferably at the same time each day. Taking it with food may improve absorption and reduce gastrointestinal upset.
Mechanism of Action
Disogen acts as an aldosterone antagonist, competing with aldosterone for receptor sites in the renal distal tubules and collecting ducts. This inhibits sodium reabsorption and potassium excretion, leading to increased water excretion and potassium retention.
Pharmacokinetics
Onset
Diuretic effect onset typically within 2-4 hours, peak effect at 6-10 hours.
Excretion
Excreted primarily in urine (27-50%) and feces (35-40%), mainly as metabolites.
Half life
Approximately 1.5 hours (for parent drug), but active metabolites have much longer half-lives (up to 16.5 hours for canrenone).
Absorption
Well absorbed orally, bioavailability is approximately 60-70%. Food may increase absorption.
Metabolism
Extensively metabolized in the liver to active metabolites, including canrenone and 7-alpha-thiomethylspironolactone.
Side Effects
Contraindications
- •Hyperkalemia (serum potassium >5.5 mEq/L).
- •Severe renal impairment (creatinine clearance <30 mL/min) or anuria.
- •Addison's disease.
- •Concomitant use of other potassium-sparing diuretics or potassium supplements.
Drug Interactions
NSAIDs
May reduce diuretic and antihypertensive effects; increased risk of hyperkalemia and renal impairment.
Lithium
Disogen may reduce renal clearance of lithium, leading to increased lithium levels and toxicity.
ACE Inhibitors / ARBs
Increased risk of severe hyperkalemia.
Potassium Supplements / Other Potassium-Sparing Diuretics
Significantly increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hyperkalemia, nausea, vomiting, diarrhea, dizziness, and lethargy. Management involves discontinuing the drug, immediate measures to reduce serum potassium (e.g., IV glucose with insulin, sodium bicarbonate, calcium gluconate), and supportive care. Hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Disogen is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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