Dobelit
Generic Name
Calcium Dobesilate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dobelit 500 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Calcium Dobesilate is a vasoprotective agent used to treat microangiopathies, particularly diabetic retinopathy, and chronic venous insufficiency, including hemorrhoids. It helps in improving capillary resistance and reducing permeability.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg daily, usually in 1-2 divided doses, depending on the severity of the condition. For hemorrhoids, 500 mg twice daily for a few weeks.
Elderly
No specific dose adjustment generally required, but caution is advised in patients with compromised renal function.
Renal_impairment
Dose reduction may be necessary in severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Orally, with or after meals to minimize gastrointestinal discomfort.
Mechanism of Action
Acts by reducing capillary permeability and improving microcirculation. It also inhibits platelet aggregation and improves blood viscosity, thereby reducing edema and improving venous tone.
Pharmacokinetics
Onset
Effects may be seen within a few days to weeks depending on the condition being treated.
Excretion
Primarily via urine (approx. 50%) and feces (approx. 50%) within 24 hours.
Half life
Approximately 5-6 hours.
Absorption
Well absorbed orally, bioavailability is around 60-80%. Peak plasma concentration is reached within 6 hours.
Metabolism
Minimally metabolized; mainly excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to Calcium Dobesilate or any component of the formulation.
- •Severe gastrointestinal bleeding (relative contraindication).
Drug Interactions
Anticoagulants
Although no significant interactions are commonly reported, caution is advised with oral anticoagulants, and INR monitoring may be prudent.
None significant
Generally considered to have a low potential for drug interactions.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances such as nausea, vomiting, or diarrhea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the risks. Limited data suggest it is excreted in breast milk, so use with caution during lactation or discontinue breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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