Dobical Plus
Generic Name
Calcium Carbonate + Vitamin D3
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dobical plus 4 2 rectal ointment | ৳ 170.00 | N/A |
Description
Overview of the medicine
Dobical Plus is a combination of Calcium Carbonate and Vitamin D3, used to supplement calcium and vitamin D in the body, which are essential for strong bones and teeth. It helps prevent and treat conditions like osteoporosis, rickets, and osteomalacia.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets daily, or as directed by physician.
Elderly
Same as adult dosage, but caution with renal impairment.
Renal_impairment
Use with caution and dose adjustment may be necessary. Monitor calcium and phosphate levels.
How to Take
Orally, preferably with meals to enhance absorption. Can be taken with water.
Mechanism of Action
Calcium Carbonate provides elemental calcium necessary for bone formation, nerve transmission, muscle contraction, and blood coagulation. Vitamin D3 (Cholecalciferol) helps the body absorb calcium and phosphorus from the gut and regulates calcium levels in the blood, facilitating bone mineralization.
Pharmacokinetics
Onset
Gradual, with effects seen over weeks to months with consistent use.
Excretion
Calcium is primarily excreted via kidneys and feces; Vitamin D3 metabolites are excreted mainly in bile and feces, and some in urine.
Half life
Calcium has a complex pharmacokinetic profile; Vitamin D3 has a half-life of about 15-30 days.
Absorption
Calcium absorption depends on the presence of Vitamin D3. Vitamin D3 is absorbed from the small intestine.
Metabolism
Calcium is not metabolized; Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), the active form.
Side Effects
Contraindications
- •Hypercalcemia (high blood calcium levels)
- •Severe hypercalciuria (high calcium in urine)
- •Nephrolithiasis (kidney stones)
- •Hypervitaminosis D
Drug Interactions
Corticosteroids
Reduce calcium absorption
Thyroid hormones
May reduce efficacy; take 4 hours apart
Thiazide diuretics
Increase risk of hypercalcemia
Tetracyclines/Fluoroquinolones
Reduce absorption; take 2-4 hours apart
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to hypercalcemia. Symptoms include nausea, vomiting, constipation, polyuria, polydipsia, and muscle weakness. Treatment involves discontinuation of the drug, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Generally considered safe and essential for pregnant and lactating women, but should be used under medical supervision to avoid excessive intake.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Not applicable (Generic combination)
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Global Brand Names
International brand names for this medicine
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