Dofixim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dofixim 40 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Dofixim 40 mg suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically for adults in this specific formulation; adult dosage for Cefixime is usually 400 mg once daily or 200 mg every 12 hours (tablet/capsule).
Elderly
Dosage adjustment not generally required unless severe renal impairment.
Renal_impairment
For pediatric renal impairment, general pediatric dose is 8 mg/kg/day; for CrCl < 20 mL/min, reduce to 4 mg/kg/day.
How to Take
Administer orally, with or without food. Shake the suspension well before each use. Use an accurate measuring device (e.g., syringe, measuring spoon) provided with the product.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the inhibition of the transpeptidation step of peptidoglycan synthesis, thereby disrupting cell wall formation and causing bacterial cell lysis.
Pharmacokinetics
Onset
Not specified, but generally within a few hours for antibiotic effect.
Excretion
Mainly through renal excretion (glomerular filtration and tubular secretion); also via biliary excretion.
Half life
About 3-4 hours.
Absorption
Approximately 40-50% absorbed from the gastrointestinal tract; food may delay absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- Hypersensitivity to penicillin (risk of cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing the risk of bleeding. Close monitoring required.
Probenecid
Increases cefixime plasma concentrations and AUC.
Carbamazepine
Increased carbamazepine levels when co-administered. Monitor carbamazepine levels.
Oral anticoagulants
Enhanced anticoagulant effect. Monitor INR/PT.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not substantially effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- Hypersensitivity to penicillin (risk of cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing the risk of bleeding. Close monitoring required.
Probenecid
Increases cefixime plasma concentrations and AUC.
Carbamazepine
Increased carbamazepine levels when co-administered. Monitor carbamazepine levels.
Oral anticoagulants
Enhanced anticoagulant effect. Monitor INR/PT.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not substantially effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). 7-14 days (reconstituted suspension, refrigerated).
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections, particularly in pediatric and ENT infections. Ongoing research focuses on resistance patterns.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- INR/PT (if co-administered with anticoagulants)
- Complete blood count (rarely with prolonged use)
Doctor Notes
- Prescribe appropriate dosage based on patient's weight and renal function.
- Educate parents on proper administration and adherence to the full course.
- Advise on potential side effects and when to seek medical attention.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Shake well before each use.
- Do not stop taking without consulting your doctor.
- Discard any unused suspension after the specified period (usually 7-14 days after reconstitution).
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Usually no effect on driving ability, but if dizziness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Ensure adequate rest.
- Avoid sharing medication.
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