For intravenous infusion only. Reconstitute each 250 mg vial with 10 mL of sterile water for injection, then dilute in 50-100 mL of 0.9% sodium chloride injection or 5% dextrose injection. Administer over 1 hour.

Doripenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death.

• •Known severe hypersensitivity to doripenem or other carbapenem antibiotics.
• •Known severe hypersensitivity (e.g., anaphylactic reaction) to other beta-lactam antibiotics (e.g., penicillins or cephalosporins).

Store unconstituted vials at 20°C to 25°C (68°F to 77°F), with excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light. Once reconstituted or diluted, solutions should be used promptly.

In case of overdose, symptomatic and supportive treatment should be initiated. Hemodialysis can remove doripenem from the body.

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Doripenem is excreted in breast milk; caution advised during lactation.