Take orally once daily, with or without food, preferably at the same time each day. Do not crush or chew the tablet.

Dotfix works by selectively inhibiting the reuptake of serotonin in the presynaptic neuronal cleft, thereby increasing the concentration of serotonin available to bind to postsynaptic receptors. This leads to an enhancement of serotonergic neurotransmission in the central nervous system.

• •Hypersensitivity to the active substance or any excipients
• •Concomitant use with MAO inhibitors (MAOIs)
• •Concomitant use with Pimozide

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and seizures. Management is symptomatic and supportive; maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered if ingested within 1-2 hours.

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.