Dotinor
Generic Name
Dotinurad
Manufacturer
Local Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dotinor 1 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Dotinor 1 mg Tablet contains Dotinurad, a medication used to treat hyperuricemia, particularly in patients with gout, by increasing the excretion of uric acid via the kidneys. It helps to lower serum uric acid levels.
Uses & Indications
Dosage
Adults
Initial dose is usually 0.5 mg once daily. After 2 weeks, the dose may be increased to 1 mg once daily, and further adjusted based on serum uric acid levels, up to a maximum of 4 mg once daily. Dotinor 1 mg tablet is suitable for the 2nd stage of dose escalation.
Elderly
No specific dose adjustment is generally required, but close monitoring of renal function is recommended due to potential age-related decline.
Renal_impairment
Dose adjustment may be necessary in moderate to severe renal impairment (e.g., eGFR < 30 mL/min/1.73 m²). Not recommended in end-stage renal disease or patients on dialysis.
How to Take
Take Dotinor 1 mg Tablet orally once daily. It can be taken with or without food. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Dotinurad selectively inhibits the urate transporter 1 (URAT1) in the renal proximal tubules. By blocking URAT1, it reduces the reabsorption of uric acid from the kidney tubules back into the blood, thereby promoting its excretion in urine and lowering serum uric acid levels.
Pharmacokinetics
Onset
Uric acid lowering effect begins within hours of administration. Sustained reduction in serum uric acid levels is observed with continued daily dosing.
Excretion
Mainly excreted via urine (approximately 80%) as both unchanged drug and metabolites, with a smaller portion excreted in feces.
Half life
The elimination half-life is approximately 2-3 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration (Tmax) is typically reached within 1-2 hours.
Metabolism
Primarily metabolized by UDP-glucuronosyltransferases (UGTs), mainly UGT1A1 and UGT1A3, in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Dotinurad or any excipients of the product.
- •Severe hepatic impairment.
- •End-stage renal disease (ESRD) or patients undergoing dialysis.
- •Known history of severe allergic reactions to uricosuric agents.
Drug Interactions
Other uricosuric agents
Co-administration with other uricosuric agents is not recommended due to potential for additive effects and increased risk of urolithiasis.
Salicylates (high dose)
High doses of salicylates (e.g., aspirin >325 mg/day) may reduce the uricosuric effect of Dotinurad.
UGT Inhibitors/Inducers
Drugs that inhibit or induce UDP-glucuronosyltransferases (UGT1A1, UGT1A3) may alter the plasma concentrations of Dotinurad. Use with caution.
Diuretics (e.g., Thiazides)
Thiazide diuretics can increase serum uric acid levels, potentially counteracting the effects of Dotinurad. Monitor uric acid levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Dotinurad. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Dotinurad is not recommended during pregnancy or lactation due to insufficient data on safety. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., PMDA in Japan)
Patent Status
Patented (originator product from Kissei Pharmaceutical)
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Global Brand Names
International brand names for this medicine
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